非那雄胺长期使用需要注意什么？非那雄胺的注意事项有哪些？

Finasteride tablets are drugs used to treat prostatic hyperplasia and male pattern baldness. Finasteride tablets are currently on the market in many countries. It is a specific inhibitor of type II 5a-reductase, an intracellular enzyme that metabolizes testosterone into dihydrotestosterone. Today let’s learn about what we need to pay attention to when using finasteride for a long time? What are the precautions for finasteride?

General precautions for finasteride:

1. Before using this product, other diseases similar to benign prostatic hyperplasia (BPH) should be ruled out, such as infection, prostate cancer, urethral stricture, bladder hypotonia, neurogenic disorders, etc.

2. Patients with renal insufficiency do not need to adjust the dosage.

3. Finasteride is mainly metabolized in the liver and should be used with caution in patients with liver dysfunction.

Patients also need to pay attention to the impact on prostate-specific antigen and prostate cancer examinations when using:

1. Finasteride has no clinical efficacy in the treatment of prostate cancer. Finasteride does not affect the incidence of prostate cancer, nor does it affect the detection rate of prostate cancer.

2. It is recommended to perform regular prostate examinations, such as digital rectal examination and other prostate cancer-related examinations (including PSA) before receiving finasteride treatment and after a period of treatment.

3. Finasteride can reduce serum PSA concentration by approximately 50% in patients with prostatic hyperplasia (or with prostate cancer). When evaluating PSA data and not excluding concomitant prostate cancer, finasteride should be considered to reduce serum PSA levels in patients with prostatic hyperplasia. 4. Patients treated with finasteride for persistently elevated PSA levels should be evaluated with caution, including consideration of non-compliance with finasteride treatment.

Women and children are contraindicated during treatment with finasteride. In addition, people who have an allergic reaction to the ingredients in the drug finasteride also need to avoid using this drug.

If the patient has a large amount of residual urine or a severe reduction in urinary flow, the urinary tract condition must be closely monitored during treatment with finasteride to avoid urinary tract obstruction. This drug should be contraindicated during pregnancy and in women who are preparing to become pregnant, otherwise it may cause abnormalities in the fetal external genitalia.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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