赛洛多辛(Silodosin)的副作用如何缓解

Silodosin is a highly selective α1A-adrenergic receptor antagonist, mainly used to treat symptoms caused by benign prostatic hyperplasia (BPH).

Side effects of Silodosin

1. Common side effects (≥5%)

Ejaculation disorders (17.2%, including retrograde ejaculation), dry mouth.

2. Common side effects (1%-5%)

(1) Genitourinary system: erectile dysfunction, urinary incontinence.

(2) Digestive system: gastric discomfort, diarrhea, soft stool, constipation.

(3) Nervous system: dizziness, instability, headache.

(4) Others: nose bleeding, nasal congestion, and fatigue.

3. Rare side effects (<1%)

(1) Cardiovascular: atrial fibrillation, palpitations, tachycardia, orthostatic hypotension.

(2) Allergy: rash, urticaria, itching.

(3) Others: Abnormal liver function (elevated AST/ALT), jaundice, tinnitus, feminized breasts.

The pictures are from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

Methods to alleviate the side effects of Silodosin

1. Orthostatic hypotension and dizziness

It is recommended that patients try to avoid sudden standing up, sudden changes in body position, etc., and especially avoid high-risk actions such as driving or operating machinery that endangers the lives of themselves or others until the drug in the body is basically eliminated.

2. Treatment of retrograde ejaculation

Although it is a common reaction to drugs and has negligible impact on the body's health, it can gradually return to normal after stopping the drug. If the patient cannot tolerate it, a different treatment plan may be considered.

3. Gastrointestinal discomfort

If diarrhea occurs, patients are advised to avoid spicy food, drink more water, and use antidiarrheal drugs temporarily if necessary. Depending on the severity of your symptoms, you should seek prompt medical attention for professional evaluation and treatment.

4. The importance of preoperative notification

Patients planning to undergo cataract surgery must inform their ophthalmologist in advance that they are using silodosin to prevent the occurrence of intraoperative floppy iris syndrome (IFIS).

Silodosin (Silodosin) Medication for Special Populations

1. Patients with renal insufficiency

Moderate injury (CCr30–50mL/min) needs to be reduced to 4mg/day, and severe injury (CCr<30mL/min) is contraindicated.

2. Patients with hepatic insufficiency

No dose adjustment is required for mild to moderate injuries, and it is contraindicated for severe injuries (Child-Pugh ≥ 10).

3. Elderly people

Pharmacokinetics may change slightly, but dosage adjustment is generally not required.

4. Men with reproductive potential

It may cause ejaculation disorders, which are mostly reversible after stopping the drug.

5. Use by children

Safety has not been established and use is prohibited.