elagolix

　　[Indications]

　　This product is a gonadotropin-releasing hormone(GnRH)receptor antagonist indicated for the relief of moderate to severe pain caused by endometriosis.

　　[Limitations of Use]

　　The duration of use should be restricted based on the dosage and any comorbid conditions.

　　[Recommended Dosage]

　　Patients with normal or mild hepatic impairment:

　　150 mg orally once daily for a maximum duration of 24 months;or 200 mg orally twice daily for a maximum duration of 6 months.

　　Patients with moderate hepatic impairment:

　　150 mg orally once daily for a maximum duration of 6 months.

　　[Adverse Reactions]

　　The most common adverse reactions(incidence>5%)include:hot flashes,night sweats,headache,nausea,insomnia,amenorrhea,anxiety,arthralgia,depression-related reactions,and mood changes.

　　[Pharmacology]

　　It competitively binds to pituitary GnRH receptors,dose-dependently inhibiting the secretion of LH and FSH,thereby reducing levels of estradiol and progesterone.

　　[Storage]

　　Store at temperatures between 2°C and 30°C.