Sevatrim

[Chinese name] Xuebijing, compound-sulfamethoxazole injection

[English Name] Sevatrim

[Original drug name] Bactrim

[Ingredients of Xuebaijing Compound Sulfamethoxazole Injection]

Each ampoule (5ml) contains: Sulfamethoxazole (Sulfamethoxazole) 400mg, trimethoprim Pyrimidine (Trimethoprim) 80 mg

Excipients: propylene glycol, dimethylamide, sodium bisulfite, water for injection

[Indications of Xuebajing Compound Sulfamethoxazole Injection]

Respiratory tract, gastrointestinal tract, and urinary tract infections caused by Gram-positive and Gram-negative bacteria.

[Function of Xuebajing Compound Sulfamethoxazole Injection]

1. Respiratory tract infections: bronchitis, pneumonia, pharyngitis, tonsillitis, sinusitis.

2. Genitourinary tract infections: gonorrhea, cystitis, nephritis, pyelitis, urethritis.

3. Gastrointestinal infections: enteritis, typhoid fever, paratyphoid fever.

4. Other infectious diseases: purulent dermatitis, boils, wound infections, sepsis and various bacterial infections.

[Usage and dosage of Xuebajing Compound Sulfamethoxazole Injection]

1. The usual dosage for adults to treat bacterial infections is 160 mg of trimethoprim and 800 mg of sulfamethoxazole (2 tablets) once every 12 hours. To treat Pneumocystis carinii pneumonia, trimethoprim 3.75-5 mg/kg and sulfamethoxazole 18.75-25 mg/kg should be taken every 6 hours. Preventive medication for adults: initially take 160 mg of trimethoprim and 800 mg of sulfamethoxazole (2 tablets) twice a day, then take the same dose once a day, or 3 times a week.

2. The usual dosage for children is prohibited for infants under 2 months old. To treat bacterial infections, infants over 2 months old and under 40kg can take SMZ 20-30mg/kg and TMP 4-6mg orally once every 12 hours according to body weight; the dosage for children weighing ≥40kg is the same as that commonly used for adults. To treat parasitic infections such as Pneumocystis carinii pneumonia, take SMZ 18.75-25mg/kg and TMP 3.75-5mg/kg orally once every 6 hours according to body weight. The course of treatment for acute exacerbations of chronic bronchitis is at least 10-14 days; the course of treatment for urinary tract infection is 7-10 days; the course of treatment for bacillary dysentery is 5-7 days; the course of treatment for acute otitis media in children is 10 days; the course of treatment for Pneumocystis carinii pneumonia is 14-21 days.

[Xuebaijing Compound-Sulfamethoxazole Injection Warning]

1. This product may cause mental-related adverse reactions such as hallucinations, depression, apathy, and nervousness.

2. This product should not be given to patients with a history of allergies to sulfa, trimethoprim or compound sulfamethoxazole.

3. It is contraindicated in patients with liver parenchymal damage.

4. Unless under certain circumstances, it should not be administered to patients with severe blood diseases.

5. If patients who receive cytotoxic agents do not have side effects on bone marrow or peripheral blood, they can be administered together.

6. It is prohibited to use this product for those with severe renal insufficiency who cannot perform repeated measurement of plasma concentration. This product cannot be given to premature infants under six weeks old and to full-term newborns.

[Precautions for Xuebijing Compound-Sulfamethoxazole Injection]

1. If rash occurs, use of this product should be discontinued.

2. Infusion overload is possible, especially when high doses are given to patients with underlying cardiopulmonary diseases. Patients with impaired renal function should adjust the dosage according to the above instructions, and preferably measure the plasma concentration. Appropriate urine flow should be maintained.

3. Elderly people: Special care is usually required when treating elderly patients, as this group of people are more sensitive to side effects and appear to suffer more severe effects.

4. When treating patients with potential folic acid deficiency, folic acid supplementation should be considered, such as the elderly.

5. In order to prolong the high-concentration dose of this product, you can also consider supplementing folic acid. If treatment with this product is prolonged, especially for patients with suspected folate metabolism disorders, it is recommended to perform a complete blood count, including platelet measurement, every month. Death is extremely rare, but death may occur from the following serious effects: Stevens-Johnson syndrome, Lyell's syndrome (toxic epithelial necrosis), explosive hepatic necrosis, agranulocytosis, aplastic anemia, blood dyscrasias, and respiratory hyperexcitability. It should be noted that in patients with severe parenchymal damage to the liver, the absorption and metabolism of trimethoprim and sulfamethoxazole may be altered.

6. Hemolysis may occur in patients with G-6-PD deficiency. Caution should be exercised when administering this product to patients with a history of severe allergies or bronchial asthma.

7. This product should not be used for pharyngitis caused by group A beta-hemolytic streptococci because it is less effective than penicillin.

8. Trimethoprim will reduce phenylalanine metabolism, but this will not have a significant impact on phenylketonuric (phenylketonuria) patients with appropriate dietary control.

9. Avoid administering this product to patients known or suspected to be at risk for porphyria. Trimethoprim and sulphonamides may worsen porphyria (although not as specific as sulfamethoxazole).

10. Patients at risk for hyperkalemia should have their serum potassium concentration monitored closely.

[Packaging]: 5 ml ampoule, box of less than 100 pieces.

【Storage】: Store below 25℃.