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Pentamidine for injection (Benambax) is an aromatic diamidine antiprotozoal drug developed by Sanofi. It is a prescription drug and is mainly used for the treatment of Pneumocystis carinii pneumonia (PCP), leishmaniasis and African trypanosomiasis in patients with immunodeficiency.
Common name :Pentamidine (Pentamidine)
Trade name :Benambax®
Dosage form : Lyophilized for injection Powder injection
Main ingredient :Pentamidine Isethionate (PentamidineIsethionate)
Kala-azar (visceral leishmaniasis) : Systemic infection caused by Leishmania.
Pneumocystis jiroveci pneumonia (PCP) : Used for the prevention and treatment of immunodeficiency patients (such as AIDS).
Specifications : Each bottle contains 300 mg of pentamidine base (equivalent to 564 mg of pentamidine isothiosulfate).
Properties : White to slightly yellow freeze-dried powder, which becomes a colorless to light yellow clear solution after reconstitution.
Kala-azar :
Adults and children: 3-4 mg/kg (base), once a day, intravenous drip or deep intramuscular injection, course of treatment for 15-20 days.
PCP treatment :
4mg/kg (base), once a day, intravenous infusion, treatment course is 14-21 days.
PCP prevention :
4mg/kg (base), once a month by aerosol inhalation or once every 2 weeks by intravenous infusion.
Reconstitution method
Dissolve in sterile water for injection or 5% glucose solution. Dilute to 1-2 mg/mL during intravenous infusion, and the infusion time is ≥ 60 minutes.
Replace missed doses of
Replenish immediately. If it is close to the next dose time, skip it. Doubling the dose is prohibited.
Renal insufficiency :
eGFR10-50mL/min: reduce the dose by 25%.
eGFR<10mL/min or dialysis: reduce the dose by 50%.
Hepatic insufficiency : Close monitoring is required, and there is no clear adjustment guide.
Administration route :
Intravenous infusion should be protected from light and rapid infusion (may cause hypotension).
Intramuscular injection may cause local pain or necrosis, so deep injection and site rotation are required.
Monitoring requirements :
Check blood sugar, blood routine, liver and kidney function, and electrocardiogram regularly before and during treatment (risk of QT interval prolongation).
Diet : No special requirements, but you need to maintain adequate water to prevent nephrotoxicity.
U200c for pregnant women: Only used when life is in danger (animals show embryotoxicity).
Lactation period : Suspend breastfeeding (the drug may be secreted into breast milk).
Children : Adjust dose based on body weight, safety data are limited.
U200c for the elderly: More prone to hypoglycemia and nephrotoxicity, the dose needs to be reduced and monitored closely.
Common (≥10%) :
Hypoglycemia (30%), nausea (20%), injection site pain (15%), renal function damage (12%).
Serious but rare :
Pancreatitis (5%), QT prolongation (3%), anaphylactic shock (<1%).
Those allergic to pentamidine or excipients.
Those with severe hypoglycemia or uncorrected electrolyte imbalance.
Early pregnancy (unless the benefits outweigh the risks).
Nephrotoxic drugs (such as aminoglycosides) : Increase the risk of kidney damage, avoid combined use.
Drugs that prolong the QT interval (such as fluoroquinolones) : may synergistically cause the risk of arrhythmia, and electrocardiogram monitoring is required.
The hypoglycemic drug : enhances the hypoglycemic effect and the dose needs to be adjusted.
Unopened : Refrigerate at 2-8℃, protected from light, valid for 36 months.
After reconstitution : Use within 24 hours at room temperature and refrigerated for no more than 48 hours.
Manufacturer :Sanofi-Aventis (Sanofi-Aventis).