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Baricitinib is a selective Janus kinase (JAK) 1/2 inhibitor that blocks the JAK-STAT signaling pathway and inhibits the intracellular signaling of multiple inflammatory cytokines (such as IL-6, IFN-γ), thereby reducing inflammatory responses and immune-mediated tissue damage.
Baricitinib (trade name: Olumiant).
1. Adults with moderate to severe active rheumatoid arthritis (those with insufficient response or intolerance to DMARDs).
2. Moderate to severe atopic dermatitis in adults and children over 2 years old (those requiring systemic treatment).
3. Severe alopecia areata in adults.
4. Active juvenile idiopathic arthritis in children over 2 years old (those who have insufficient response to traditional or biological DMARDs).
2mg, 4mg, tablet .
Each tablet contains 2mg or 4mg of baricitinib. .
1. Conventional dosage of :
Rheumatoid arthritis/atopic dermatitis/alopecia areata: 4 mg once a day is recommended for adults, and 2 mg once a day is recommended for high-risk patients (such as ≥65 years old).
Children’s atopic dermatitis/juvenile arthritis: 4mg once a day for those ≥30kg, 2mg once a day for those 10-30kg.
2. How to take : Take it orally at a fixed time every day. It can be taken with food or on an empty stomach.
1. Renal insufficiency (CrCl30-60mL/min): 2 mg/day for adults, half for children.
2. Use strong OAT3 inhibitors (such as probenecid): reduce the dose by half.
3. After the treatment response is insufficient or stable: the dose can be adjusted (4mg↔2mg).
1. Missed dose of : If you miss a dose, you should take it as soon as possible. If it is close to the next dose time, skip it. Do not take double dose.
2. Vomiting : If you vomit after taking the medicine, there is no need to take a supplement, and you can take the medicine next time as originally planned.
3. Children's medication : Those who cannot swallow the whole tablet can be dispersed in water and taken.
1. Pregnant women : Disabled, effective contraception is required during medication and within 1 week of discontinuation.
2. U200c during lactation: Disabled.
3. Elderly people (≥75 years old) : Data are limited, use with caution.
4. Patients with liver damage : It is contraindicated in severe liver damage.
1. Common : increased LDL (26%), upper respiratory tract infection (16.9%), headache (5.2%).
2. Serious risks : infection (including tuberculosis), venous thrombosis, malignant tumors, and gastrointestinal perforation.
1. Those who are allergic to ingredients.
2. Pregnancy period.
3. Active tuberculosis/severe infection.
1. Immunosuppressant : Avoid combined use of biological agents/other JAK inhibitors.
2. OAT3 inhibitor : If probenecid will increase the blood concentration, the dosage needs to be reduced.
3. Live vaccine : Avoid vaccination during medication.
Not clearly stated. It is generally recommended to avoid light and dry storage. Please refer to the packaging instructions for details.