Nebimac

Common name: Nebivolol

Trade name: Nebimac

All names: Nebivolol, Nebivolol hydrochloride, Nebivolol hydrochloride, Nebivolol hydrochloride, Nebicip, Bystolic, Nebivolol, Nebimac

[Nebivolol/Nebimac indications]

Nebivolol treats hypertension and arrhythmia.

[Nebivolol/Nebimac usage and dosage]

Can be taken with or without food. Individualized to patient needs and monitored during titration.

Hypertension: Most patients start with 5mg daily.

The dose can be increased every 2 weeks, up to a maximum of 40mg.

[Nebivolol/Nebimac Adverse Reactions]

This product has fewer adverse reactions. The most common ones are headache, dizziness, fatigue, paresthesia, constipation, diarrhea, etc. These adverse reactions are usually transient and rarely lead to discontinuation of treatment. This product does not cause orthostatic hypotension and rarely induces heart failure or severe bradyarrhythmia.

[Nebivolol/Nebimac contraindications]

Severe bradycardia.

Heart block is greater than first degree.

Patients with cardiogenic shock.

Compensated heart failure.

Sick sinus syndrome (unless you have a permanent pacemaker).

Patients with severe hepatic insufficiency (Child-Pugh> B).

Allergy to any ingredients in this product.

[Nebivolol/Nebimac Precautions]

Acute exacerbation of coronary artery disease after stopping the drug: Do not stop the drug suddenly.

Diabetes: Monitor blood sugar as beta blockers may mask symptoms of hypoglycemia.

CYP2D6 enzyme inhibitors may increase nebivolol levels.

Reserpine or clonidine may cause excessive reduction in sympathetic activity.

Both digitalis glycosides and beta-blockers slow atrioventricular conduction and lower heart rate.

Concomitant use may increase the risk of bradycardia.

Verapamil or diltiazem calcium channel blockers may cause excessive decreases in heart rate, blood pressure, and cardiac contractility.

Breastfeeding is not recommended.

[Nebivolol/Nebimac Storage]

Store at 20° to 25°C (68° to 77°F (Fahrenheit))

[Nebivolol/Nebimac Mechanism of action]

Nebivolol, as a third-generation beta-receptor antagonist, is different from other beta-receptor antagonists. It combines a highly selective beta-receptor antagonist with nitric oxide-mediated vasodilation, which has a beneficial effect on endothelial function. It is well tolerated by patients with hypertension and heart failure.

[Nebivolol/Nebimac Safety and Efficacy]

A 4-week multi-center double-blind randomized placebo-controlled parallel group dose study involving 509 patients with hypertension showed that the effect of 0.5 to 10 mg in reducing systolic and diastolic blood pressure was dose-related. A dose of 2.5 mg or more once a day can achieve significant antihypertensive effects. The antihypertensive effect of 5 mg once a day was significantly better than 2.5 mg or placebo. The antihypertensive effect of 10 mg once a day is no better than 5 mg.

In a multi-center double-blind placebo-controlled trial study of 114 patients with essential hypertension, it was found that nebivolol, taken 5 mg daily for 8 weeks, could reduce supine and standing blood pressure, slow down the heart rate and diastolic blood pressure to normal or reduce it by more than 10% in 65% of cases.

Multiple multi-center randomized double-blind controlled studies in patients with mild to moderate hypertension have shown that the antihypertensive effect of 5 mg or 10 mg of this product per day is equivalent to 50 mg of atenolol, 100 mg of metoprolol, 20 mg of nifedipine extended-release preparation twice a day, or 10 mg of lisinopril per day; significantly better than the efficacy of enalapril 10 mg per day, hydrochlorothiazide 25 mg per day, and placebo.