Nebilet

[Indications of Nebivolol]

Nebivolol treats hypertension and arrhythmia.

[Nebivolol ingredients]

nebivolol (as hydrochloride) Nebivolol

[Nebivolol usage and dosage]

Adults

It is recommended to take one tablet of Nebivolol (5 mg) at a fixed time every day.

There is a significant blood pressure lowering effect after taking the medicine for 1 to 2 weeks. Usually the maximum effect is achieved after taking the medicine for 4 weeks.

Patients with renal insufficiency

For patients with renal insufficiency, the recommended starting dose is 2.5 mg daily. If necessary, the dose can be adjusted to 5 mg daily.

Geriatric patients

For patients over 65 years of age, the recommended starting dose is 2.5 mg per day. If necessary, the dose can be adjusted to 5 mg daily.

Usage

Oral administration. This medicine can be taken with meals.

[Nebivolol Good Reactions]

This product has few adverse reactions, the most common ones are headache, dizziness, fatigue, paresthesia, constipation, diarrhea, etc. These adverse reactions are usually transient and rarely lead to discontinuation of treatment. This product does not cause orthostatic hypotension and rarely induces heart failure or severe bradyarrhythmia.

[Nebivolol contraindications]

Severe bradycardia.

Heart block is greater than first degree.

Patients with cardiogenic shock.

Compensated heart failure.

Sick sinus syndrome (unless you have a permanent pacemaker).

Patients with severe hepatic insufficiency (Child-Pugh> B).

Allergy to any ingredients in this product.

[Nebivolol Precautions]

Acute exacerbation of coronary artery disease after stopping the drug: Do not stop the drug suddenly.

Diabetes: Monitor blood sugar as beta blockers may mask symptoms of hypoglycemia.

CYP2D6 enzyme inhibitors may increase nebivolol levels.

Reserpine or clonidine may cause excessive reduction in sympathetic activity.

Both digitalis glycosides and beta-blockers slow atrioventricular conduction and lower heart rate.

Concomitant use may increase the risk of bradycardia.

Verapamil or diltiazem calcium channel blockers may cause excessive decreases in heart rate, blood pressure, and cardiac contractility.

Breastfeeding is not recommended.

[Storage of Nebivolol]

Store at 20° to 25°C (68° to 77°F (Fahrenheit))

[Mechanism of action of Nebivolol]

As a third-generation beta-receptor antagonist, nebivolol is different from other beta-receptor antagonists in that it combines a highly selective beta-receptor antagonist with nitric oxide-mediated vasodilation, which has a beneficial effect on endothelial function. It is well tolerated by patients with hypertension and heart failure.

[Safety and Efficacy of Nebivolol]

A four-week multi-center double-blind randomized placebo-controlled parallel group dose study involving 509 patients with hypertension showed that the effect of 0.5 to 10 mg in reducing systolic and diastolic blood pressure was dose-related. A dose of 2.5 mg or more once a day can achieve significant antihypertensive effects. The antihypertensive effect of 5 mg once a day was significantly better than 2.5 mg or placebo. The antihypertensive effect of 10 mg once a day is no better than 5 mg.

In a multi-center double-blind placebo-controlled trial study of 114 patients with essential hypertension, it was found that nebivolol, taken 5 mg daily for 8 weeks, could reduce supine and standing blood pressure, slow down the heart rate and diastolic blood pressure to normal or reduce it by more than 10% in 65% of cases.

Multiple multi-center randomized double-blind controlled studies in patients with mild to moderate hypertension have shown that the antihypertensive effect of 5 mg or 10 mg of this product per day is equivalent to 50 mg of atenolol, 100 mg of metoprolol, 20 mg of nifedipine extended-release preparation twice a day, or 10 mg of lisinopril per day; significantly better than the efficacy of enalapril 10 mg per day, hydrochlorothiazide 25 mg per day, and placebo.