Diacomit

Usage and Dosage

Standard dose:50mg/kg/day, taken in 2-3 times (maximum daily dose 3000mg)

Dosage method:< /b>

Capsules: swallow whole, with a glass of water during meals

Suspension: mix with 100mL of water and take immediately, then add 25mL of water to rinse

Dose adjustment

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1. Missed dose: Take the dose immediately, skip if it is close to the next dose time

2. Vomiting: No need to take the next dose, take the next dose as originally planned

< b>3. Withdrawal of medication:Need to gradually reduce the dose (sudden withdrawal of medication may induce status epilepticus)

Precautions for medication

1. Taking time:Must be taken with meals to improve High absorption

2. Special handling:

Capsules cannot be broken or chewed

The suspension must be prepared for immediate use and must not be stored

3. Monitoring requirements :Check the blood routine before taking the drug and every 6 months

Using the drug in special groups

Pregnant women: It may cause fetal malformations, so the pros and cons need to be weighed (Pregnancy Registration No. 1-888-2 33-2334)

Lactation period:No relevant data, it is recommended to suspend breastfeeding

Children:Safety under 2 years old has not been established

Liver Renal insufficiency:Not recommended for moderate to severe patients

Adverse reactions

Common (≥10%): Drowsiness (67%), decreased appetite (45%), coma Disorders (27%), weight loss (27%)

Serious adverse reactions: Neutropenia (13%), thrombocytopenia (13%), QT interval prolongation

Contraindications

There are no absolute contraindications, but suspensions (containing phenylalanine) are contraindicated in patients with phenylketonuria

Drug interactions

1. Increase the concentration: Make chlorine The concentration of Bazam and its metabolites increases 2-5 times (needs to reduce the dosage by 25%)

2. Contraindicated combinations: Strong CYP1A2/CYP3A4 inducers (such as rifampicin)