A.T.10

Actions and clinical pharmacology: DHT is hydroxylated in the liver to 25-hydroxydihydrotachysterol, which is the main circulating active form of the drug. It is not further hydroxylated by the kidneys and is therefore an analogue of 1,25-dihydroxyvitamin D. DHT effectively increases serum calcium levels by stimulating intestinal calcium absorption and mobilizing bone calcium in the absence of parathyroid hormone and a functioning kidney. organize. It also increases renal phosphate excretion. In contrast to parathyroid extract, dihydrotachysterol is active when taken orally, exerts a slow and long-lasting effect, and can be used long-term without increasing the dose or causing tolerance. DHT acts faster than pharmacological doses of vitamin D and is less persistent after discontinuation of treatment. Indications and clinical uses: Acute, chronic and latent forms of postoperative tetany, idiopathic tetany and hypoparathyroidism.

Contraindications: In patients with hypercalcemia, hypersensitivity to dihydrotachysterol and high vitamin D.

Note: To prevent hypercalcemia, treatment should always be controlled by regular determination of calcium levels in blood and urine, mainly during the initiation of treatment until the required maintenance dose is established.

Usage and dosage: For oral administration only. Treatment depends on the nature and severity of the disease and must be individualized. Serum calcium levels should remain within the normal range (9 to 10 mg/mL).

Oral calcium lactate or calcium gluconate (10 to 15 mg daily) may reduce the dose.

Adults and Geriatrics: Acute Cases: Initial Dose: In acute cases, 6 to 10 capsules (0.75 to 1.25 mg) for 3 days. Estimates of serum and urinary calcium should be determined 2 or 3 days after the initial treatment period.

Maintenance dose: Usually take 2 to 14 capsules (0.25 to 1.75 mg) per week in divided doses. Precise dosage depends on serum and urinary calcium measurements.

Chronic Disease: In chronic disease, an initial dose of 4 capsules (0.5 mg) taken daily or every other day may be sufficient to maintain normocalcemia.

Dosage must usually be increased during menstruation and during periods of unusual activity.

Children: No specific dosage recommendations.

Adverse reactions: Adverse reactions are most likely caused by overdose, manifesting as symptoms of hypercalcemia.

The first signs are: loss of appetite, nausea.

More severe symptoms include: vomiting, urgency, polyuria, dehydration, thirst, dizziness, stupor, headache, abdominal cramps and paralysis. Serum concentrations of calcium and phosphorus are increased.

Chronic overdose: With long-term overdose, calcium may be deposited in many tissues, including arteries and kidneys, leading to high blood pressure and kidney failure.