怎么用利伐沙班？

How to use rivaroxaban? Rivaroxaban is a prescription drug and must be prescribed by a doctor according to the condition of the patient, and must be taken according to the doctor's instructions, including usage, dosage, medication time, etc. Rivaroxaban is taken orally, 10 mg of rivaroxaban, once daily. If the wound has stopped bleeding, the first medication should be administered between 6 and 10 hours after surgery. Can be taken with food or alone. Rivaroxaban 15 mg or 20 mg should be taken with food. The length of rivaroxaban treatment is based on each patient's risk of venous thromboembolic events.

Prevention of deep vein thrombosis after hip replacement: 10 mg, once a day, 35 days of treatment.

Prevention of deep vein thrombosis after knee replacement: 10 mg, once a day, 12 days of treatment.

For the treatment of deep vein thrombosis and pulmonary embolism: The dose is 15 mg twice daily with meals for 21 days. For maintenance treatment and to reduce the risk of deep vein thrombosis and pulmonary embolism, the dose is 20 mg once daily with a meal.

For reducing the risk of stroke in non-valvular atrial fibrillation: 20 mg orally once daily with dinner. For patients who are underweight and older than 75 years old, 15 mg once a day can be used as appropriate.

When rivaroxaban was combined with ketoconazole (400 mg once daily [od]) or ritonavir (600 mg twice daily [bid]), the average AUC of rivaroxaban increased by 2.6 times/2.5 times, and the average Cmax of rivaroxaban increased by 1.7 times/1.6 times. At the same time, the drug efficacy was significantly improved, which may lead to an increased risk of bleeding. Therefore, coadministration of rivaroxaban with azole-antifungal agents (such as ketoconazole, itraconazole, voriconazole, and posaconazole) or systemic HIV protease inhibitors is not recommended. These active substances are potent inhibitors of CYP3A4 and P-gp. Fluconazole is expected to have a small effect on rivaroxaban plasma concentrations and can be used with caution.