Rivaroxaban对静脉血栓有效果吗？

In recent years, new anticoagulant drugs Factor Xa (FXa) inhibitors have received more and more attention among anticoagulant drugs, among which they are representative drugs of FXa inhibitors. Rivaroxaban is a small molecule oral anticoagulant jointly developed by Bayer and Johnson & Johnson, with the trade name Xarelto. Rivaroxaban is an oxazolidinone-derived selective FXa inhibitor that acts on the active site of factor So what is the effect of taking Rivaroxaban on the treatment of venous thrombosis?

Rivaroxaban is a highly selective, oral drug that directly inhibits factor Xa. Compared with warfarin, its effect is safe, effective and lasts for a long time, and does not require monitoring of coagulation. By inhibiting factor

Rivaroxaban does not inhibit thrombin (activated factor II) and has no proven effect on platelets. A dose-dependent inhibition of factor Xa activity by Rivaroxaban has been observed in humans. Rivaroxaban's effect on prothrombin time (PT) has a dose-effect relationship. If NeopLastin is used for content measurement, it is closely related to plasma concentration (correlation coefficient is 0.98). Different results may occur with other reagents. Reading the PT should be completed within seconds because the International Normalized Ratio (INR) is calibrated and validated only for coumarins and not for other anticoagulants.

The recommended dose is Rivaroxaban 10 mg orally once daily. If the wound has stopped bleeding, the first medication should be administered between 6-10 hours after surgery. The length of treatment is determined by each patient's risk of VTE, i.e. by the type of orthopedic surgery the patient has undergone. For patients undergoing major hip surgery, a recommended course of treatment is 5 weeks. For patients undergoing major knee surgery, a recommended course of treatment is 2 weeks. If a dose is missed, the patient should take Rivaroxaban immediately and continue taking it once a day the next day. Patients can take rivaroxaban with a meal or on its own.

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