利伐沙班最佳服药时间

(Rivaroxaban) is a relatively new oral anticoagulant drug. It has high patient tolerance and stable anticoagulant effect. It does not require monitoring of the patient's coagulation function during the medication period, making it very convenient to use. In addition, the drug half-life of rivaroxaban is relatively short, and the interaction with other drugs is very small. It will not cause many adverse reactions after taking the drug, and it is very safe and reliable. So, when is the best time to take rivaroxaban?

Under normal circumstances, if the patient's wound has stopped bleeding, the first medication should be administered between 6 and 10 hours after the operation. The recommended dose is 10 mg orally, once a day.

From the perspective of pharmacokinetics and pharmacodynamics, rivaroxaban can be rapidly absorbed in healthy people, with peak concentrations reaching the highest levels 2 to 4 hours after a single dose of 1.25-80 mg or multiple doses. Studies have shown that rivaroxaban inhibits the activity of factor Xa in a dose-dependent manner. The strongest inhibition occurs 1 to 4 hours after administration. When a single dose of 5 to 80 mg is taken, the maximum inhibition rate is 20% to 61%. After multiple doses per day, there is no significant difference in the maximum inhibition of factor xa activity. Rivaroxaban prolongs the prothrombin time (PT) and activated partial thromboplastin time (APTT) in a dose-dependent manner, and the degree of inhibition of factor Xa activity is closely related to the plasma concentration of rivaroxaban.

At present, rivaroxaban (i.e. Xarelto) has been approved for use in many countries and regions including China, the United States, and the European Union. The CFDA and FDA have clarified the indications of rivaroxaban. For different types of diseases, the recommended dosage and medication duration are different, and each indication has a tailor-made dosage plan. Therefore, patients must undergo a medical examination before taking medicine and receive symptomatic treatment. The specific usage must also follow the doctor's advice or take the medicine according to the instructions.

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