拜瑞妥是什么药物？

(Rivaroxaban) is a highly selective, oral drug that directly inhibits factor xa. By inhibiting factor xa, it can interrupt the endogenous and exogenous pathways of the coagulation waterfall, inhibit the generation of thrombin and thrombosis, and has a safe, effective, simple and intuitive anticoagulant effect. Today let’s take a closer look at what kind of drug Xarelto is?

Xarelto (rivaroxaban) is mainly indicated for the treatment of venous thrombosis in adults. It is also used in adult patients undergoing elective hip or knee replacement surgery to prevent venous thrombosis (VTE). It is used to treat venous thrombosis (DVT) in adults and reduce the risk of DVT recurrence and pulmonary embolism (PE) after acute DVT. For use in adult patients with non-valvular atrial fibrillation who have one or more risk factors (e.g., congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, history of stroke or transient ischemic attack) to reduce the risk of stroke and systemic embolism.

How to take Xarelto (rivaroxaban):

1. To prevent venous thrombosis in adult patients undergoing elective hip or knee replacement surgery: The recommended dose is oral Xarelto (Xarelto) 10 mg, once daily. If the wound has stopped bleeding, the first dose of medication should be between 6 and 10 hours after surgery. For patients undergoing major hip surgery, the recommended course of treatment is 35 days. For patients undergoing major knee surgery, the recommended course of treatment is 12 days. If a missed dose occurs, patients should take Xarelto immediately and continue taking the dose once daily the next day.

2. Treat DVT (venous thrombosis) and reduce the risk of acute DVT recurrence and PE: The recommended dose of Xarelto (rivaroxaban) for the initial treatment of acute DVT is 15 mg twice a day for the first three weeks, and then the dosage for maintenance treatment and reducing the risk of DVT recurrence and PE is 20 mg once a day.

3. For use in adult patients with non-valvular atrial fibrillation to reduce the risk of stroke and systemic embolism: The recommended dose of Xarelto (rivaroxaban) is 20 mg once a day, which is also the maximum recommended dose. For patients with low weight and advanced age (>75 years old), doctors can use 15 mg once a day as appropriate based on the patient's condition.

Xarelto is an oral, bioavailable Factor Xa inhibitor that selectively blocks the active site of Factor Xa and does not require cofactors (such as antithrombin III) for activity. Factor X is activated into factor Xa (FXa) through endogenous and exogenous pathways, which plays an important role in the coagulation cascade.

The above is the introduction to the drug (Rivaroxaban), I hope it can help you!

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