用拜瑞妥需要注意什么事项？

Rivaroxaban is one of the new oral anticoagulant drugs currently in use. At present, there is only the original drug, trade name, which can inhibit the generation of thrombin and thrombosis. The mechanism of action is a highly selective inhibition of free and bound factor It is used to prevent thrombosis in non-valvular atrial fibrillation (atrial fibrillation) and arterial embolism, especially cerebral artery embolism (stroke). It can also be used to prevent and treat venous thrombosis in the lower limbs, especially in patients undergoing joint replacement surgery and who have been bedridden for a long time, to prevent the occurrence of pulmonary embolism.

What should I pay attention to when using Xarelto?

1. Bleeding risk: Some subgroups of patients have a higher risk of bleeding. After treatment with Xarelto, these patients should be closely monitored for signs of bleeding complications. This can be accomplished by regular physical examination of the patient, close observation of surgical wound drainage, and regular determination of hemoglobin. Any unexplained decrease in hemoglobin or blood pressure should prompt a search for the site of bleeding. 

2. Impact on the ability to drive and use machinery: There is no research on the impact on the ability to drive and use machinery. There have been reports of syncope and dizziness after surgery, which may affect the ability to drive and use machinery, but reports indicate that these adverse reactions are uncommon. Patients experiencing these adverse reactions should not drive or use machinery. 

3. Liver damage: In cirrhotic patients with moderate liver damage (Child Pugh category B), the plasma concentration of rivaroxaban may be significantly increased, leading to an increased risk of bleeding. Rivaroxaban can be used with caution in patients with cirrhosis who have moderate hepatic impairment (Child Pugh category B) and are not accompanied by coagulation abnormalities. 

4. Interactions with other drugs: Pay attention when using it simultaneously with azole-antifungal agents (such as ketoconazole, itraconazole, voriconazole and posaconazole).

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