环丝氨酸在国内有售吗？

(cycloserine) is a second-line anti-tuberculosis drug. It is a broad-spectrum antibacterial drug and has weak antibacterial effects against many Gram-positive and -negative bacteria. In 1982, the FDA approved the listing of cycloserine capsules from Eli Lilly and Company. Today we will learn more about whether cycloserine is available in the country?

The domestically produced version of cycloserine is a domestically produced version. Cycloserine was launched in my country in the 1970s. In 2013, the cycloserine capsule developed by Zhejiang Hisun Pharmaceutical was approved by the CFDA for production and marketing, with the trade name "Selaixing". But cycloserine is not included in medical insurance. Cycloserine, produced by Macleods Pharmaceuticals in India, comes in a box of 250mg*60 capsules and is sold in Indian pharmacies for about $500. Patients in need can go abroad to purchase drugs, or obtain drugs through domestic professional overseas medical service organizations (such as Medical Companion Travel), which are guaranteed to be genuine.

Cycloserine can block two enzymes required for bacterial cell wall synthesis - alanine racemase and D-alanine ligase. Without these two enzymes, Mycobacterium tuberculosis cannot synthesize peptidoglycan, which is the main component of its cell wall. Therefore, cycloserine inhibits the reproduction of Mycobacterium tuberculosis by preventing its cell wall synthesis.

Cycloserine can only be taken orally. The conventional dose is 500mg-1g per day, and the blood drug level is monitored and taken in divided doses. It is not advisable to drink alcohol during application. 1. For adults, take 0.5-1g per day, divided into 2 times. In the first 2 weeks, you can take 0.25g each time, 2 times a day. The maximum dose is 1g per day. 2. For children, take 5 to 20 mg/kg per day, divided into 2 to 4 times, with half the dose for the first dose. It is not advisable to use cycloserine in combination with isoniazid and ethionamide to avoid additive effects on the central nervous system and increased neurotoxicity.

When using cycloserine, special groups must consider the particularity of the drug's absorption, metabolism, organ development, psychological and physiological characteristics, and master the medication principles, precautions, and medication characteristics of patients of different ages and constitutions at different stages; according to the specific conditions of the patients, formulate the best medication plan to achieve the best clinical efficacy, minimize adverse reactions, and achieve rational medication use.

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