【用药建议】静脉栓塞吃拜瑞妥多少mg？下肢深静脉血栓拜瑞妥要吃多久？

Xarelto is the world's first clinically applied inhibitor that directly acts on coagulation factor Xa. It was jointly developed by Bayer Pharmaceuticals of Germany and Johnson & Johnson of the United States. In the study of Xarelto, it was found that the degree of inhibition of factor Xa and factor IIa, the prolongation of APTT, and the prolongation of PT were positively correlated with the dose, indicating that the pharmacodynamics of Xarelto are predictable; at the same time, Xarelto does not require routine monitoring of coagulation function and routine dose adjustment, so it can improve patients' medication compliance. How many mg should patients with venous thrombosis take? How long should I take Xarelto for deep vein thrombosis of the lower limbs?

Xarelto Dosage

The recommended dose of Xarelto is 10 mg of Xarelto taken orally once daily. If the wound has stopped bleeding, the first dose of medication should be between 6 and 10 hours after surgery.

For patients undergoing major hip surgery, Xarelto recommends a 35-day course of treatment. For patients undergoing major knee surgery, the recommended course of treatment is 12 days. If a missed dose occurs, patients should take Xarelto immediately and continue taking the dose once daily the next day.

For use in adult patients with non-valvular atrial fibrillation to reduce the risk of stroke and systemic embolism: The recommended dose of Xarelto is 20 mg once a day, which is also the maximum recommended dose. For patients with low body weight and advanced age (>75 years old), doctors can use 15 mg once a day as appropriate based on the patient's condition.

Xarelto treats DVT (venous thrombosis) and reduces the risk of acute DVT recurrence and PE: The recommended dose for the initial treatment of acute DVT is 15 mg twice daily for the first three weeks, and then the dose for maintenance treatment and reducing the risk of DVT recurrence and PE is 20 mg once a day.

Since each patient's disease stage and personal constitution are different, the specific dosage and specific time required for patients to receive Xarelto treatment are different, which is determined by the patient's disease stage and personal constitution. When receiving drug treatment, patients should not increase or decrease the dose of the drug without authorization. Increasing the drug will not improve the condition quickly, but will lead to adverse reactions. Therefore, the medication should be strictly followed as prescribed by the doctor.

The absorption of Xarelto depends on the site of release of the drug in the gastrointestinal tract, and administration of rivaroxaban in the distal stomach should be avoided. Relevant foreign studies have shown that the area under the receiver operating characteristic curve (AUC) and Cmax of Xarelto are dose-dependent, and no accumulation effect occurred in subjects at any dose, indicating that Xarelto has high safety and tolerability within a large dose range in healthy people. In this regard, patients can purchase and use this medicine with confidence. 

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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