利伐沙班作用机制是什么？有什么禁忌和注意事项吗？

As a substitute for low molecular weight heparin and warfarin, Rivaroxaban has been used as a first-line clinical anticoagulant in orthopedic surgery and cardiology departments. In recent years, this drug has also received widespread attention in other disciplines, especially in the anticoagulant treatment of malignant tumors combined with deep vein thrombosis. Rivaroxaban is one of the new oral anticoagulant drugs currently in use. It can inhibit the generation of thrombin and thrombosis and is mainly used to treat venous thrombosis in adults. What's the mechanism of action? Are there any taboos and precautions?

Rivaroxaban mechanism of action

Rivaroxaban is an oral, bioavailable factor Xa inhibitor that selectively blocks the active site of factor Xa and does not require cofactors (such as antithrombin III) for activity. Factor X is activated into factor Xa (FXa) through endogenous and exogenous pathways, which plays an important role in the coagulation cascade.

This medicine should not be used in patients with severe hypersensitivity to rivaroxaban or any of its components, patients with clinically significant active bleeding, or patients with liver disease with coagulation abnormalities and risk of clinically relevant bleeding.

Treatment with Rivaroxaban may cause harm to the fetus. Therefore, pregnant and lactating women should not use this drug for treatment. Patients should take effective contraceptive measures during drug treatment.

There are no studies on the effects of rivaroxaban on the ability to drive and use machinery. However, there have been reports of syncope and dizziness after surgery, which may affect the ability to drive and use machinery. Therefore, patients should pay special attention and try to avoid driving a vehicle or operating machinery while taking drugs.

The above is an introduction to Rivaroxaban. If patients want to know more drug information about Rivaroxaban, they can consult the Medical Companion Travel Service.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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