阿司匹林与利伐沙班可以联用吗？

Cerebral infarction can lead to cerebral ischemia, hypoxia, and local brain tissue necrosis. Its disability and mortality rates are extremely high, and its recurrence rate is high. Therefore, early and effective secondary prevention treatment is of great significance in reducing the recurrence of cerebral infarction. Aspirin is the drug of choice for the secondary prevention of cerebral infarction. It can inhibit platelet aggregation by inhibiting the production of platelet thromboxane A2. However, some patients will develop aspirin resistance, leading to an increased risk of recurrence. It is a new oral anticoagulant drug that can directly inhibit the activity of factor Xa and interfere with thrombin by interfering with the cascade reaction of coagulation factors, protecting blood vessels, prolonging PT and APTT, reducing Fib levels, and inhibiting thrombosis.

So, can aspirin and rivaroxaban be used together?

Although both aspirin and rivaroxaban can prevent thrombosis, their mechanisms of action are different and they cannot replace each other. Aspirin is mainly used for the prevention of atherosclerosis-related diseases such as myocardial infarction, cerebral infarction, coronary heart disease, and severe carotid artery stenosis. Rivaroxaban is mainly used to prevent pulmonary embolism caused by venous thrombosis and cerebral infarction caused by atrial fibrillation. If both risk factors exist, aspirin and rivaroxaban can be used together. Experiments have confirmed that the combined use of the two has a more significant effect in vascular protection and increases patient benefits. However, the combined use of the two will also increase the risk of gastrointestinal bleeding, so before using the two together, it needs to be evaluated by a doctor and used with caution.

At present, the flow of information on the Internet is very convenient and fast, which makes some unsubstantiated gossip spread very quickly. Recently, there has been a lot of non-authoritative information saying that simply increasing the dose of the drug can improve the therapeutic effect of the drug, and some say that reducing the dose of the drug can avoid the occurrence of some side effects. These are without any basis and can also mislead patients. The editor would like to remind all patients who are taking rivaroxaban to follow the doctor's instructions carefully to take the medication, so as to maximize the effect of the drug itself.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.