利伐沙班片治疗房颤用法用量？

Nonvalvular atrial fibrillation (NVAF) is a global medical problem, and its prevalence increases with age, with the prevalence reaching 17% in people over 80 years old. Increasing age is an independent risk factor for ischemic stroke. Oral anticoagulants (OACs) can significantly reduce the incidence of stroke by 64% and all-cause mortality by 26%. As a non-vitamin K antagonist (NOACs), it is widely used in the prevention and treatment of NVAF. So, do you know the usage and dosage of rivaroxaban tablets in the treatment of atrial fibrillation?

Rivaroxaban tablets usage and dosage for treating atrial fibrillation

It is 20 mg once a day, which is also the maximum recommended dose. For patients with low body weight and advanced age (>75 years old), doctors can use 15 mg once a day as appropriate based on the patient's condition.

Cautions should be taken when using Rivaroxaban tablets

1. Rivaroxaban tablets are not recommended for patients who are receiving systemic azole antifungal drugs (such as ketoconazole, itraconazole, voriconazole, posaconazole) or HIV protease inhibitors (such as ritonavir). These drugs are strong inhibitors of CYP3A4 and P-gp and, therefore, may increase plasma concentrations of this drug to clinically relevant levels leading to an increased risk of bleeding. Fluconazole has a small effect on the exposure of this product and can be used with caution.

2. Patients should be cautious if they also use non-steroidal anti-inflammatory drugs, platelet aggregation inhibitors or other anti-thrombotic drugs that affect hemostasis.

3. When using axonal anesthesia (spinal/epidural anesthesia) or spinal/epidural puncture, the epidural catheter should be removed 18 hours after the last administration of this product. The next dose of this product should be administered 6 hours after the catheter is removed. If it is an invasive puncture, the administration of this product should be delayed for 24 hours.

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