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Rivaroxaban is a small molecule oral anticoagulant jointly developed by Bayer and Johnson & Johnson, with the trade name Xarelto. Rivaroxaban is a highly selective, oral drug that directly inhibits factor xa. By inhibiting factor xa, the endogenous and exogenous pathways of the coagulation cascade can be interrupted, and the generation of thrombin and thrombosis can be inhibited. Rivaroxaban does not inhibit thrombin and has no proven effect on platelets. A dose-dependent inhibition of factor xa activity by rivaroxaban has been observed in humans.

Any medicine will have certain side effects. Side effects are drug effects that occur at therapeutic doses and are unrelated to the therapeutic purpose and are generally unavoidable. What are the common side effects of rivaroxaban?

The most common side effect of Rivaroxaban is bleeding. Anticoagulant drugs all have a risk of bleeding, but the risk of clinical major bleeding is relatively low. Hemorrhagic complications may manifest as weakness, weakness, pallor, dizziness, headache, or unexplained swelling. Therefore, the possibility of bleeding should be considered when evaluating patients taking anticoagulants. Secondly, some patients may also experience allergic reactions, such as urticaria, dermatitis, etc. There are also some patients who may have a certain impact on liver and kidney function, causing an increase in creatinine and transaminases. Some relatively rare side effects include abnormal blood vessels, abnormal number of platelets, changes in coagulation function, etc.

Other side effects of rivaroxaban: agranulocytosis, anaphylactic shock, anaphylaxis, angioedema, cerebral hemorrhage, cholestasis, decreased hemoglobin, DRESS syndrome (drug eruption with eosinophilia and systemic symptoms), injection site hematoma, hemiplegia, hematuria, hepatitis, liver damage, allergic reaction, intracranial hemorrhage, jaundice, retroperitoneal hemorrhage, spinal hematoma, Stevens-Johnson syndrome, subdural hematoma, thrombocytopenia.