氢化可的松片(hydrocortisone)常见副作用

Common side effects: iatrogenic Cushing's syndrome, face and posture, weight gain, lower limb edema, purple lines, easy bleeding tendency, poor wound healing, acne, menstrual disorders, avascular necrosis of the humeral or femoral head, osteoporosis and fractures (including vertebral compression fractures, long bone disease rational fractures), muscle weakness, muscle atrophy, hypokalemic syndrome, gastrointestinal irritation (nausea, vomiting), pancreatitis, peptic ulcer or perforation, growth inhibition in children, glaucoma, cataracts, benign intracranial hypertension syndrome, impaired glucose tolerance and exacerbation of diabetes mellitus.

Patients may experience psychiatric symptoms: euphoria, agitation, delirium, restlessness, disorientation, and may also manifest as inhibition. Psychiatric symptoms are particularly likely to occur in people suffering from chronic wasting diseases and those who have had mental disorders in the past.

Complicated infections are the main adverse reactions of adrenocortical hormones: fungi, Mycobacterium tuberculosis, Staphylococcus aureus, Proteus, Pseudomonas aeruginosa and various herpes viruses. 

Glucocorticoid withdrawal syndrome: Sometimes patients experience dizziness, fainting tendencies, abdominal or back pain, low-grade fever, loss of appetite, nausea, vomiting, muscle or joint pain, headache, fatigue, and weakness after stopping the drug. After careful examination, if adrenal insufficiency and relapse of the original disease can be ruled out, glucocorticoid dependence syndrome can be considered.

It is prohibited for those allergic to other steroid hormones. Patients with the following diseases are generally not suitable for use. In special cases, the pros and cons should be weighed, but attention should be paid to the possibility of worsening of the condition: severe mental illness (past or present) and epilepsy, active peptic ulcer disease, recent gastrointestinal anastomosis surgery, fractures, trauma repair period, corneal ulcers, hyperadrenocorticism, hypertension, diabetes, pregnant women, fungal infections that cannot be controlled by antibiotics, chickenpox, measles, severe osteoporosis, etc.