莫努匹韦作用和副作用是怎样的？应该怎么服用莫努匹韦？

Monupivir is a nucleoside analogue and is an oral antiviral drug used to treat adult patients with mild to moderate COVID-19 who are at risk of exposure. The drug was jointly developed by Merck and another biotechnology company called Ridgeback. It can inhibit the replication of a variety of RNA viruses, including the new coronavirus, and has the advantages of convenient administration, low cost, and easy expansion of production.

So, what are the effects and side effects of Monupivir?

The interim results of the phase III clinical trial announced by Merck showed that after 29 days of follow-up, among patients who took 4 pills of monopivir twice a day for 5 consecutive days, the hospitalization rate was 7.3%, and there were no deaths; in terms of effectiveness, monopivir reduced the risk of hospitalization or death by about 50%. In addition, monopivir has shown consistent efficacy in different new coronavirus variants, including the Delta variant and the Myriad variant. Among patients who received placebo, 14.1% were hospitalized or died, including eight deaths. Diarrhea, nausea, dizziness and headache are the main side effects of monupivir, and the overall safety profile is tolerable.

So, how should you take monupivir? Monupivir is undoubtedly a "dazzling" presence among the new coronavirus specific drugs. The drug can not only reduce the risk of hospitalization or death by half, but also has the advantage of being taken orally. Monupivir should be taken as soon as possible after diagnosis of COVID-19 or within 5 days of the onset of symptoms, with the recommended dose being 800 mg (four 200 mg capsules) taken orally every 12 hours for 5 days. The safety and effectiveness of monupivir when administered for more than 5 days has not been established. Monupivir can be taken with or without food, but it is important to note that the capsules should not be opened, crushed, or chewed, and should be swallowed whole with plenty of liquid (such as a glass of water).

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

Recommended related articles: