辉瑞新冠药不能与哪些药同服？

Pfizer's new coronavirus drug (Paxlovid), as a new oral treatment for COVID-19, has performed well in clinical studies, reducing the risk of hospitalization or death in patients with COVID-19 by 89%. It also has the advantages of being less susceptible to drug resistance and effective against mutant strains. It is considered to be a treatment method that will change the current epidemic prevention and control strategy. However, it is worth noting that because it contains the CYP3A4 enzyme inhibitor ritonavir, it interacts with many drugs and affects liver and kidney function, which greatly limits the number of people who can take it, and increases the risk of taking the drug for people with underlying diseases and the elderly. So, which drugs cannot be taken with Pfizer's new coronavirus drug?

Which drugs should not be taken with Pfizer's new coronavirus drug?

During the use of Paxlovid, the antihypertensive drug eplerenone, the antianginal drug ranolazine, the anti-inflammatory drug colchicine and the anticoagulant drug rivaroxaban are prohibited.

However, patients with underlying diseases still need some drugs to delay the disease, and cannot completely stop taking them. The following drugs can be used, but the drugs need to be replaced or discontinued and restarted 3 days after the end of Paxlovid treatment.

1. Antihypertensive drugs: irbesartan, flusartan, and nosartan.

2. Antiarrhythmic drugs: Digoxin.

3. Anti-angina drugs: labetalol.

4. Immunosuppressant: Mycophenolic acid.

5. Anti-inflammatory drugs: dexamethasone, methylprednisolone, and prednisone.

6. Anticoagulant drugs: clopidogrel, warfarin, apixaban.

Dosage of Paxlovid for special populations

When using Paxlovid, it should be used within 5 days of the onset of symptoms. A course of treatment only needs to be used for 5 days and taken twice a day. Patients with normal liver and kidney function take two pink pills + 1 white pill each time, while patients with poor liver and kidney function need to reduce the dosage and take 1 pink pill + 1 white pill each time.

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