来法莫林(Xenleta)国内价格是多少

The domestic price of Xenleta is not yet clear. For specific prices, please consult the hospital pharmacy or medical service organization.

What is the domestic price of Xenleta?

Up to now, we have not learned about the public price in the Chinese mainland market, and the price of the drug may change dynamically. For specific costs, please consult the hospital pharmacy or regular pharmacy in the listed area.

Factors affecting the price of Xenleta

1. R&D and intellectual property costs

As a new drug approved in 2019, Xenleta is backed by a high-investment clinical research and development process that lasts for several years. High R&D costs and patent protection policies are the main reasons for its relatively high price in the early stages of launch.

2. Production technology and dosage forms

Lefamoren provides both intravenous injection and oral tablet dosage forms. The production of injectables, sterility assurance and complex cold chain transportation requirements, as well as the formulation technology used to improve oral bioavailability, all increase their overall production costs.

3. Medical insurance policy and market access

Whether a drug is included in the national or local medical insurance catalog is the most critical factor in determining the actual price paid by patients. If it is included in medical insurance, the patient's out-of-pocket payment ratio will be significantly reduced. In addition, different hospitals’ procurement policies and drug delivery times will also affect their accessibility.

The pictures come from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

Precautions for using Xenleta

1. Contraindications and core warnings

(1) Contraindications: It is prohibited for those who are allergic to Xenleta, pleuromutilins or any component of this product. Oral lefamoren is strictly contraindicated in combination with CYP3A4 substrates that can prolong the QT interval (such as pimozide).

(2) QT interval prolongation: This drug has the risk of prolonging the QT interval of the electrocardiogram, which may cause serious arrhythmia. It is prohibited to be used in patients with existing QT prolongation, specific arrhythmias, or patients taking Class IA/III antiarrhythmic drugs. If necessary, electrocardiogram monitoring is required.

(3) Embryo-fetal toxicity: Animal studies show that it has teratogenic risks. The pregnancy status of women of childbearing potential must be verified before use, and they should be informed to take effective contraceptive measures during treatment and within 2 days after the last dose.

2. Medication for special groups

(1) Patients with liver dysfunction: Lefamoline oral tablets are not recommended for patients with moderate (Child-Pugh B) or severe liver damage.

(2) Pregnant and lactating women: Pregnant women should avoid use. Breastfeeding women should suspend breastfeeding during medication and within 2 days after the last dose.

(3) Elderly patients and patients with renal insufficiency: No dose adjustment is required, including patients receiving hemodialysis.

3. Drug interaction management

(1) Avoid combined use: oral lefamoren should be avoided to be used simultaneously with strong CYP3A/P-gp inhibitors (such as ketoconazole) and strong CYP3A/P-gp inducers (such as rifampicin). The former will increase the risk of adverse reactions, and the latter will reduce the efficacy.

(2). Monitor carefully: When used in combination with moderate CYP3A/P-gp inhibitors, adverse reactions need to be monitored.

4. Response to common adverse reactions

(1) Gastrointestinal reactions: The most common adverse reactions of oral tablets are diarrhea, nausea and vomiting. If you have watery stools or severe diarrhea accompanied by fever and abdominal pain, you need to be alert to Clostridium difficile infection and seek medical attention immediately.

(2) Other reactions: Intravenous administration may cause injection site reactions; both dosage forms may cause an increase in liver enzymes and require regular monitoring.