能倍乐 思力华噻托溴铵的效果好吗

Is Tiotropium bromide effective? Respimat, Siliva, and Tiotropium bromide are long-acting anticholinergic drugs that have selective inhibitory effects on M3 receptors. They have the advantages of long maintenance of blood concentration and minimal side effects. The effect of Respimat lasts for 24 hours, which means that it only needs to be used once a day to achieve long-term treatment.

Chronic obstructive pulmonary disease (COPD) is a type of chronic bronchitis and/or emphysema characterized by airflow obstruction, which can further develop into common chronic diseases such as cor pulmonale and respiratory failure. It is related to the abnormal inflammatory response of harmful gases and harmful particles, and has a high disability and mortality rate. The global incidence rate for people over 40 years old has been as high as 9% to 10%. Respimat, Tiotropium, and Tiotropium bromide dilate bronchial smooth muscle by binding to M3 receptors on smooth muscle.

In human airways, Respimat has a high affinity for receptors and dissociates slowly from muscarinic M1 and M3 receptors, and can block cholinergic nerve-mediated contraction of bronchial smooth muscle for a long time. However, Respimat dissociates from the muscarinic M2 receptor quite quickly, thus showing unique kinetic selectivity for M1 and M3 receptors.

The approval of Tiotropium bromide for Respimat and Slivar was based on data from two pivotal Phase III trials (TONADO-1, -2). The study involved more than 5,000 COPD patients. Data showed that compared with placebo, tiotropium bromide, and olodaterol monotherapy, Respimat produced a statistically significant improvement in patients' lung function (FEV1) and had a similar safety profile to tiotropium bromide or olodaterol.

The above is an introduction to the effects of Tiotropium Bromide. I hope it will be helpful to you.

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