罗氟司特是什么药？治什么病？

What is roflumilast? What disease does it cure? Roflumilast is a second-generation phosphodiesterase 4 (PDE4) inhibitor approved by the US FDA in 2011 for the treatment of chronic obstructive pulmonary disease. It has multiple effects such as anti-inflammatory, anti-tumor, anti-alcohol addiction and anti-diabetes. In recent years, it has been discovered that, like other PDE4 inhibitors, it also has neuroprotective effects, especially on cognitive function. In a variety of animal models, it can improve the induced cognitive dysfunction and effectively improve the cognitive function of patients. Therefore, it may be used as a potential therapeutic drug for central neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Its mechanism of action is mainly related to the regulation of cAMP signal transduction pathways and related signaling molecules.

Roflumilast is a long-acting inhibitor of selective phosphodiesterase type 4 (PDE-4) and has anti-inflammatory effects. Phosphodiesterases are a family of enzymes including at least 11 subtypes of enzymes that catalyze the decomposition of the messenger molecules cyclic adenosine monophosphate and/or cyclic guanosine monophosphate. Phosphodiesterase-4 is a major cyclic adenosine monophosphate metabolic enzyme in inflammatory and immune cells, and phosphodiesterase-4 inhibitors have broad anti-inflammatory activities including inhibiting the release of inflammatory mediators and inhibiting immune cell activation. In addition, phosphodiesterase-4 inhibitors have also been shown to have therapeutic effects in animal models of airway inflammation.

It is not currently listed in China, so it is not eligible for medical insurance. In other words, if patients want to purchase the drug, they must go abroad to purchase it. Traveling abroad to buy medicines is a long journey and requires a lot of manpower and material resources. Coupled with the huge medical expenses, many patient families are overwhelmed. However, according to Medical Companion Travel, 500μg*90 tablets of roflumilast costs approximately $2,850 per box. Since the exchange rate has been in a state of fluctuation for a long time, the price fluctuates with the exchange rate and is not static. For more information about roflumilast, please contact Medical Companion Travel for details.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.