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The European Union approved the marketing of roflumilast tablets in July 2010 for the treatment of chronic obstructive pulmonary disease (COPD). Roflumilast tablets, a selective phosphodiesterase 4 (PDE4) inhibitor, are the first new class of COPD treatment drugs approved by the EU in more than a decade. In vitro experiments and animal model tests have shown that roflumilast tablets have extensive anti-inflammatory effects. In vitro, roflumilast N-oxide can affect many cell types, including neutrophils, monocytes/macrophages, CD4+ and CD8+ T cells, endothelial cells, epithelial cells, smooth muscle cells, and fibroblasts. By affecting these cells, roflumilast tablets act on multiple links in the pathogenesis of chronic obstructive pulmonary disease COPD. In vivo, roflumilast tablets have an effect on multiple aspects of the pathogenesis of chronic obstructive pulmonary disease (COPD), such as tobacco-induced pulmonary inflammatory response, respiratory ciliary dyskinesia, pulmonary fibrosis, emphysema, airway remodeling, oxidative stress response, pulmonary vascular remodeling and pulmonary hypertension, etc.

Four phase III clinical studies laid the foundation for the approval of this product. More than 3,000 patients with chronic obstructive pulmonary disease (COPD) were included in two pivotal placebo-controlled clinical studies. Studies have shown that roflumilast film tablets can significantly improve patients with moderate to severe exacerbations and prediastolic FEV1, regardless of whether it is combined with a long-acting β2 agonist. The study also demonstrated that roflumilast film tablets significantly improved patients' lung function compared with placebo.

Where can I buy Roflumilast tablets? Roflumilast film tablets are not marketed in China, so patients cannot purchase the drug in domestic pharmacies. It is understood that the current cost-effective roflumilast film tablets are 500μg*90 tablets and sell for about $2,850 per box. The price is not fixed due to factors such as exchange rate fluctuations. If patients want to know the specific price information of this drug, or want to purchase cost-effective roflumilast overseas, they can consult with domestic reliable overseas medical service companies (such as Medical Companion Travel).

The above is the introduction about roflumilast, I hope it can help everyone.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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