用药指南：罗氟司特不能与哪些药一起吃

Patients need to understand the indications, dosage, and drug interactions before taking the medication to avoid other complications if the medication is not used. The following is the medication guide for roflumilast compiled by the editor:

The recommended dose of roflumilast for patients with COPD is one tablet of 500 mcg per day, with or without food. Roflumilast is administered orally and is metabolized to N-oxide by cytochrome oxidase P450 (CYP) 3A4 and CYP1A2 enzymes after entering the body. The activity of roflumilast N-oxide is only 2 to 3 times weaker than that of roflumilast, and it also has high PDE-4 selectivity. About 90% of the PDE-4 inhibitory effect in the human body is produced by roflumilast N-oxide, and the other 10% is produced by the prototype of roflumilast.

Which drugs should not be taken with roflumilast: Use with CYP3A4 inhibitors or dual inhibitors of CYP3A4 and CYP1A2 (eg, erythromycin, ketoconazole, fluvoxamine, enoxacin, cimetidine) will increase systemic exposure and may lead to increased adverse reactions. The risks of such concurrent use should be carefully weighed against the benefits.

Roflumilast is an oral preparation that is mainly expressed on inflammatory cells related to asthma, including eosinophils, neutrophils and mast cells. The drug can specifically act on a certain enzyme involved in smooth muscle contraction, thereby blocking the transmission of pro-inflammatory response signals. It has anti-inflammatory activity and has achieved good results in the clinical treatment of asthma and COPD. Smooth muscle contraction is one of the hallmarks of bronchospasm, a sudden narrowing of the airways that can cause breathing difficulties and respiratory diseases. Roflumilast also significantly delayed the worsening of respiratory symptoms and improved patients' quality of life.

At present, roflumilast is not yet on the market in China. Patients in need can contact Medical Companion Travel to obtain drug information.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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