那些年，我们了解过的明星药之罗氟司特

Chronic obstructive pulmonary disease (COPD) is a chronic bronchitis and/or emphysema characterized by airflow obstruction, which can further develop into common chronic diseases such as pulmonary heart disease and respiratory failure, with high disability and mortality rates. It is a phosphodiesterase-4 (PDE-4) inhibitor drug that has been approved for the treatment of COPD abroad, and it has been pointed out that it has certain advantages in improving lung function. Next, I will take you to learn about the star drug-roflumilast.

Roflumilast is an oral, potent and selective phosphodiesterase-4 inhibitor that provides a new method for the treatment of COPD. Roflumilast can act on PDE4 in various inflammatory cells such as neutrophils and macrophages in the airways of COPD patients, reducing the degradation of cyclic adenosine monophosphate (cAMP), thereby reducing the release of inflammatory mediators, reducing the expression of inflammatory markers on the cell surface and cell apoptosis, blocking pro-inflammatory response signal transmission, and producing a broad anti-inflammatory effect.

Studies have reported that roflumilast can increase the transcription of anti-inflammatory genes, reduce the level of inflammatory transmitters, and induce the phagocytosis function of neutrophils. At the same time, roflumilast can also significantly relieve the symptoms and improve the condition of COPD patients by reducing oxidative stress and improving hormone resistance.

The recommended dose of roflumilast for patients with COPD is 500 mcg once daily, with or without food. Common side effects of roflumilast include influenza, insomnia, headache, back pain, weight loss, dizziness, diarrhea, nausea, decreased appetite, etc. During the period of using roflumilast, it is recommended that patients strictly follow the doctor's instructions to take the medication in order to maximize the effect of roflumilast.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.