罗氟司特疗效好不好？罗氟司特会耐药吗

Roflumilast is an oral selective phosphodiesterase 4 (PDE4) inhibitor. This drug selectively inhibits PDE4 and blocks the transmission of inflammatory response signals, thereby inhibiting the damage to lung tissue caused by respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma. Is it effective? Will Roflumilast be resistant?

Four phase III clinical studies laid the foundation for the approval of roflumilast. More than 3,000 patients with chronic obstructive pulmonary disease (COPD) were included in two pivotal placebo-controlled clinical studies. Studies have shown that roflumilast can significantly improve patients with moderate to severe exacerbations and prediastolic FEV1, regardless of whether it is combined with a long-acting β2 agonist. Roflumilast significantly improved lung function compared with placebo.

Roflumilast resistance

Roflumilast can become resistant. Because each patient's physical condition is different, the time it takes for them to develop resistance, the manifestations of resistance, and the treatment plan after treatment with roflumilast will be different after receiving roflumilast treatment. How long it takes for resistance to develop after treatment with roflumilast is mainly determined by the patient's condition, personal constitution, and tolerance to the drug.

If a patient develops drug resistance during treatment with roflumilast, he or she should go to the hospital immediately for a detailed physical examination. The doctor will recommend the best treatment plan based on the patient's physical condition. Patients should not blindly use other drug treatments after becoming resistant to roflumilast, because this may produce some adverse reactions and affect the condition.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

Recommended related articles: