【用法用量】罗氟司特应如何使用？治疗期间要注意什么

Chronic obstructive pulmonary disease (COPD) is a long-term condition in which the airways and air sacs in the lungs become damaged or blocked, making it difficult to breathe. Roflumilast is indicated for the maintenance treatment of patients with severe chronic obstructive pulmonary disease (COPD) whose FEV1 is less than 50% of predicted after bronchodilator therapy. How should it be used? What should I pay attention to during treatment?

How to use roflumilast

Maintenance dose of roflumilast: One tablet daily, 500 micrograms (mcg), can be taken with or without food. Start treatment with a dose of 250 mcg once daily for 4 weeks. Thereafter, increasing to once daily dose of 500 mcg can reduce treatment discontinuation rate in some patients. The dosage and duration of treatment with roflumilast will vary depending on the patient's disease progression and physical condition. The actual dosage can be adjusted according to the patient's physical condition and tolerance to the drug.

Treatment with roflumilast may lead to psychiatric disorders, including suicide, insomnia, anxiety, depression, etc. Patients who develop the above symptoms during treatment should go to the hospital promptly, and prescribers should carefully evaluate the risks and benefits of continuing treatment with roflumilast.

Treatment with roflumilast may cause weight loss, so patients should monitor their weight regularly. If unexplained or clinically significant weight loss occurs, patients should be promptly evaluated for weight loss and consideration should be given to discontinuing roflumilast.

When using roflumilast, attention should be paid to drug interactions, and the use of this drug with strong cytochrome P450 enzyme inducers (such as rifampicin, phenobarbital, carbamazepine, phenytoin, etc.) should be avoided. If the patient is taking other medications, he or she should inform the doctor before receiving roflumilast, and the doctor can diagnose whether they can be taken at the same time.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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