布地奈德在国内上市了？

Is it listed in China? Budesonide is already on the domestic market, and my country approved its import in November 2001.

Budesonide is a light beige solid chemical substance, a glucocorticoid with highly effective local anti-inflammatory effects. It can enhance the stability of endothelial cells, smooth muscle cells and lysosomal membranes, inhibit immune responses and reduce antibody synthesis, thereby reducing the release and activity of allergic active mediators such as histamine. It can also reduce the enzymatic process triggered when antigens and antibodies are combined, inhibit the synthesis and release of bronchoconstrictor substances and reduce the contraction reaction of smooth muscles. It is clinically used in patients with glucocorticoid-dependent or independent bronchial asthma and asthmatic chronic bronchitis.

Pharmacological effects: 1. Induces the synthesis of lipocortin and inhibits phospholipase A2, reducing the production and release of lipid inflammatory mediators such as platelet activating factor, leukotrienes, prostaglandins and other lipid inflammatory mediators generated by the hydrolysis of membrane phospholipids catalyzed by this enzyme. 2. Induce the expression of angiotensin I converting enzyme and neutral endopeptidase, respectively accelerate the production of angiotensin II, and degrade and inactivate bradykinin and tachykinin; inhibit the expression of nitrous oxide synthase and reduce the production of nitrous oxide. Thereby constricting blood vessels, or reducing the effects of various other active substances other than vasotensin II on dilating blood vessels, causing inflammation, and inducing neurogenic inflammatory reactions. In addition, it can also induce the production of the vasoconstrictor substance angiocortin. 3. Inhibit the expression of various cytokines, such as interleukins 1, 3, 4, 6, and 8, tumor necrosis factor, and granulocyte colony-stimulating factor. Reduce the role of the above factors in airway inflammation, especially chronic inflammation. 4. Promote the expression of adrenergic β2 receptors and increase sensitivity to endogenous and exogenous medicinal β2 receptor agonists. 5. Immunosuppressive effect: It has an inhibitory effect on the entire immune process from the phagocytosis of antigens, the division, proliferation and differentiation of lymphocytes to the effector period.