Budesonide适合什么人用？

Who is budesonide () suitable for? Budesonide is used in patients with glucocorticoid-dependent or -independent bronchial asthma and asthmatic chronic bronchitis. Enema of this product can be used for patients with mild or moderate colonic Crohn's disease and ulcerative colitis limited to the sigmoid colon.

The study subjects were 15 patients with distal active colitis. Divided into two groups: one group of 8 patients, oral administration of Budesonide (Budesonide) 9mg qd; Group of 7 patients, oral administration of Budesonide (Budesonide) 3mg tid. The degree of symptom improvement was evaluated at 0, 4, and 8 weeks. Colonoscopy was performed at 0 and 8 weeks, and budesonide concentrations in the mucosal biopsies were measured. Results: The peak concentration of the drug in the 9 mg qd group was higher than that in the 3 mg tid group, the systemic effect was also stronger, and the inhibitory effect of hormones was more obvious. There were no differences in the area under the plasma concentration curve and drug effects between the two groups (14% decrease in lymphocytes and 26% increase in neutrophils). Budesonide concentrations were high in the distal colon biopsy mucosa in both groups. After 8 weeks, 71% of patients in the 9 mg qd and 38% of the 3 mg tid groups had improved symptoms. In the 9 mg qd group, the endoscopic index improved from 10±2 to 2±3; in the 3 mg tid group, the endoscopic index improved from 9±2 to 4±417 (P = 0102).

Conclusion: This study demonstrates that Budesonide is able to reach the distal colon and rectum. Further study of the effects of budesonide in the intestinal mucosa is needed, and a control group is necessary. Budesonide is effective in treating distal colitis with few side effects. Large clinical trials are necessary to confirm the effectiveness of budesonide and evaluate possible side effects.

From the above information, we can know that budesonide () is suitable for patients with bronchial asthma and asthmatic chronic bronchitis.