莱博雷生的说明书：作用与功效,用法用量,副作用,注意事项

Lemborexant is a new insomnia treatment drug developed by Japan's Eisai Company, with the trade name Dayvigo. As a dual orexin receptor antagonist, the drug regulates the sleep-wake cycle by specifically blocking the action of orexin neurotransmitters and is suitable for the treatment of insomnia in adults. The following will introduce in detail the mechanism of action of this drug, the correct method of use, possible side effects and precautions for use.

The effects and efficacy of leborexine

It exerts its effect in treating insomnia through a unique pharmacological mechanism, and its action characteristics are worthy of attention.

Mechanism of action

Leborexen selectively blocks orexin receptors OX1R and OX2R, inhibiting wakefulness signal transmission. This mechanism is closer to the physiological sleep process and is different from the extensive neural suppression of traditional sleeping pills.

Therapeutic effect

Clinical studies show that the drug can significantly shorten the time to fall asleep and reduce the number of nighttime awakenings. Patients often report improved sleep quality and fewer residual effects such as next-day sleepiness.

This drug is not marketed in China and is currently only approved for use in Japan, the United States and other countries. If domestic patients want to use it, they need to obtain it through specific channels.

Leborexant usage and dosage

The correct use of Leborexen is crucial to reducing adverse reactions.

Conventional dosage

The recommended starting dose is 5mg, taken within 30 minutes before going to bed. Based on efficacy and tolerability, the dose may be increased to 10 mg, with the maximum dose not exceeding 10 mg/day.

Adjustment for special groups

Old people over 65 years old should start with 5mg. The maximum dose for patients with moderate hepatic impairment is 5 mg, and it is contraindicated for patients with severe hepatic impairment. Dosage adjustments are usually not required in patients with renal insufficiency.

Leboracine Side Effects and Precautions

Understanding the adverse reactions and usage precautions of Leboracine is very important for safe medication use.

CNS depressant effects and daytime impairment

Leborexen can depress the central nervous system, which may lead to a decrease in daytime awakening ability even at normal doses. In some patients, this inhibitory effect may continue for several days after stopping the drug. After taking leborexan, patients may experience drowsiness, which may affect driving and other activities requiring high alertness. This risk increases significantly when sleep deprivation or overdose occurs.

Sleep paralysis, hypnotic/hypnotic hallucinations, and cataplexy-like symptoms

Patients may experience an inability to move or speak during sleep-wake transitions, including vivid and disturbing sensations, which may be distressing to the patient.

Complex sleep behaviors

After using Lebrasen, patients may develop complex sleep behaviors such as sleepwalking and sleepwalking driving. These behaviors are usually not remembered by the patients. Concomitant use with alcohol or other CNS depressants may increase the risk of these complex sleep behaviors.

Avoid coadministration of leborexan with strong CYP3A inhibitors. It is not advisable to drink alcohol while taking the medicine. The effects of medications should be evaluated before engaging in work that requires high alertness, and mood changes should be monitored for patients with a history of depression.