雷美替胺(Ramelteon)的功效与作用

Ramelteon is a prescription hypnotic drug that needs to be used under the guidance of a doctor.

Effects and effects of Ramelteon

1. Indications

Improve the difficulty in falling asleep in patients with insomnia.

2. Adapt to the crowd

Adult insomnia patients who have difficulty falling asleep.

Usage and dosage of Ramelteon

1. Recommended dose

8 mg, once a day.

2. Medication time

Take it within 30 minutes before going to bed.

3. How to take the medicine

The tablet should be swallowed whole and should not be broken, crushed or chewed before taking.

4. Dose adjustment for special groups

(1) Hepatic insufficiency

Moderate liver damage: Use ramelteon with caution and monitor for adverse reactions.

Severe liver impairment (Child-Pugh C grade): Disabled.

(2) Renal insufficiency: including patients with end-stage renal disease, no dose adjustment is required.

(3) Elderly people: No dose adjustment is required, and the safety is equivalent to that of young adults.

(4) Children: Safety and effectiveness have not been established.

The pictures are from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

Precautions for Ramelteon

1. Severe allergic reaction

Rare but possible angioedema of the tongue, throat or larynx, accompanied by symptoms such as difficulty breathing, nausea and vomiting, requires immediate medical attention and this product must not be used again.

2. Complex sleep behaviors

Including "sleep driving" (driving while not fully awake after taking medication), preparing food, making phone calls, having sex, etc., which cannot be recalled afterwards. Once this occurs, the medication should be discontinued immediately.

3. Abnormal thinking and behavioral changes

Hallucinations, agitation, anxiety, worsening of depression and even suicidal thoughts may occur, especially patients with a history of mental illness need to be closely observed.

4. Endocrine effects

Long-term use may cause a decrease in testosterone levels and an increase in prolactin levels. Symptoms include female menstrual disorders, non-lactation lactation, loss of sexual desire or infertility. If you experience such symptoms, you should consult your doctor.

Ramelteon (Ramelteon) drug interactions

1. Concomitant use of drugs is prohibited

Fluvoxamine maleate: can strongly inhibit ramelteon metabolizing enzymes (CYP1A2, etc.), resulting in a significant increase in the blood concentration of ramelteon and enhanced efficacy. Concomitant use is prohibited.

2. Concomitant medications that need attention

(1), CYP1A2 inhibitors: such as quinolone antibacterial drugs, may increase the blood concentration of ramelteon and enhance the efficacy, so caution is required when used in combination.

(2) CYP2C9 inhibitors: such as the azole antifungal drug fluconazole, may increase the blood concentration of ramelteon and enhance the drug efficacy (for example, fluconazole can increase the peak concentration and area under the drug-time curve of ramelteon), so caution is required when used together.

(3) CYP3A4 inhibitors: such as the azole antifungal drug ketoconazole, may increase the blood concentration of ramelteon and enhance the efficacy, so caution is required when used together.