雷美替胺(Ramelteon)国内价格是多少

Ramelteon, developed by Takeda Pharmaceuticals of Japan, is a selective melatonin receptor agonist.

What is the domestic price of Ramelteon?

The price of 8mg medicine in the US market is about US$75 per box of 100 tablets. The price only reflects legal overseas information and does not make any purchase recommendations or price commitments, nor is it used for domestic sales.

Factors affecting the price of Ramelteon

1. Patented and generic drugs

During the patent protection period of the original drug, the price is usually higher. Once generic drugs appear, market competition will significantly lower prices. Knowing whether there are generic drugs on the market in your area is the key to controlling costs.

2. Drug dosage forms and specifications

Tablets are the standard dosage form of ramelteon. Different packaging specifications will have different unit prices.

3. Supply chain and distribution channels

The more intermediate links such as wholesalers and retailers that go through from the pharmaceutical factory to the patients, the greater the price increase is likely to be.

The pictures are from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

Indications of Ramelteon

1. Indications

Improve the difficulty in falling asleep in patients with insomnia.

2. Adapt to the crowd

Adult insomnia patients who have difficulty falling asleep.

Adverse reactions of Ramelteon

1. Major side effects (unknown frequency)

Allergic reactions: urticaria, angioedema, etc. may occur, the drug must be stopped immediately and appropriate measures must be taken.

2. Other side effects

(1) Psychological and nervous system: dizziness, headache, drowsiness (incidence rate 0.1%-5%); nightmares (frequency unknown).

(2) Skin: rash (incidence rate 0.1%-5%).

(3) Digestive organ: constipation, nausea (incidence rate 0.1%-5%).

(4) Endocrine: elevated prolactin (the frequency is unknown, seen in foreign clinical trials, and the domestic incidence is unclear).

(5), Others: Burnout (incidence rate 0.1%-5%), suicidal tendencies (unknown frequency).

Ramelteon (Ramelteon) Medication for Special Populations

1. Pregnant women

It should only be used when the benefits of treatment outweigh the potential risks. Animal experiments (150 mg/kg/day and above) have shown that Ramelteon may cause teratogenicity such as fetal diaphragm hernia and skeletal variation.

2. Breastfeeding women

It is necessary to weigh the benefits of treatment and the benefits of breastfeeding before deciding whether to continue breastfeeding or discontinue the drug (animal tests show that the drug can enter the milk).

3. Use in children

Clinical trials for children have not yet been carried out, and safety has not been established.

4. Use by the elderly

The blood concentration of the drug may increase due to metabolic characteristics. When taking the drug, the patient's status must be closely observed and the drug administered with caution.

5. Liver function impairment

(1) Patients with severe liver dysfunction: Contraindicated. Ramelteon is mainly metabolized by the liver, which may lead to a significant increase in blood concentration.

(2) Patients with mild to moderate hepatic dysfunction: Caution is required as blood drug concentration may increase due to slowed metabolism.