长期使用盐酸舍曲林对身体是否有害？舍曲林有副作用吗？

Sertraline is an antidepressant drug that has a good therapeutic effect on patients with depression in clinical practice. It can effectively alleviate the depressive symptoms of depressed patients, such as irritability, anxiety, fatigue, etc. It is currently the drug of choice for the treatment of depression. The tablets are administered orally once a day, in the morning or evening. Today let’s find out whether long-term use of sertraline hydrochloride is harmful to the body? Does sertraline have any side effects?

There are still quite a few. Clinical data shows:

Gastrointestinal: Diarrhea/loose stools, dry mouth, indigestion, and nausea.

Metabolism and Nutrition: Anorexia.

Nervous system: Dizziness, drowsiness and tremor.

Mental: Insomnia.

Reproductive system and breast glands: sexual dysfunction (mainly delayed ejaculation in men).

Skin and subcutaneous tissue: excessive sweating.

Blood and Lymphatic System: Neutropenia and Thrombocytopenia.

In a multi-dose clinical trial comparing sertraline and placebo for the treatment of depression, common side effects of sertraline compared with the placebo group were: diarrhea/watery stools, dry mouth, indigestion, and nausea. Anorexia. Dizziness, sleepiness and tremors. Insomnia. Erectile dysfunction (the key is delayed ejaculation in men). Sweat easily. Side effects observed in double-blind, placebo-controlled trials in patients with OCD were similar to those observed in clinical studies in patients with anxiety disorders.

Sertraline is a powerful and specific 5-hydroxytryptamine reuptake retardant for nerve cells outside the body, which can increase the serotonin effect in the body of animals. Sertraline has only a minimal effect on the reuptake of norepinephrine hormone and choline in nerve cells. In clinical medical usage, sertraline blocks the uptake of 5-5-hydroxytryptamine by human platelets and is one of the preferred drugs for treating depression and anxiety disorders today.

Sertraline has no affinity for muscarinic, serotonergic, dopamine, adrenergic, histamine, GABA, or benzodiazepine receptors. Long-term administration of sertraline to animals can downregulate norepinephrine receptors in the brain, which is consistent with the clinical effects of other antidepressant drugs.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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