戊聚糖多硫酸钠(爱泌罗)出现视网膜色素改变怎么办？

The incidence rate of interstitial cystitis is currently high in all countries, and most of them are female patients. Data show that the global incidence rate of this disease in women is about (52~500)/100,000, while the incidence rate in men is on the rise. (Amirol) is mainly used to treat interstitial cystitis Caused by bladder pain (in 1996, the US FDA approved the first legal oral medication specifically for the pain and discomfort of IC.), or interstitial cystitis combined with chronic prostatitis suprapubic pain, or simple chronic prostatitis syndrome suprapubic pain. But what should I do if retinal pigment changes occur after using sodium pentosan polysulfate (Amerol)?

Retinal pigment changes in pentosan polysulfate sodium (Amerol)

Long-term use of pentosan polysulfate sodium (almerol) may cause retinal pigment changes. Although most of these cases occurred after 3 years or more of use, cases with shorter durations of use have been observed. Although the cause is unknown, cumulative dose appears to be a risk factor. Symptoms in reported cases include difficulty reading, slow adjustment to low-light or reduced light conditions, and blurred vision.

Pentosan polysulfate sodium (Amirol) processing method

A detailed ophthalmic history should be obtained from all patients before initiating treatment with pentosan polysulfate sodium (Amerol). If there is a family history of hereditary patterns of malnutrition, genetic testing should be considered. For patients with pre-existing ophthalmic disease, a comprehensive baseline retinal examination (including color fundus photography, ocular coherence tomography (OCT), and autofluorescence imaging) is recommended before initiating treatment. Baseline retinal examinations (including OCT and autofluorescence imaging) are recommended for all patients within 6 months of starting treatment and periodically during continued treatment. If pigmentary changes occur in the retina, the risks and benefits of continued treatment should be re-evaluated as these changes may be irreversible. Follow-up retinal examinations should be continued, given that retinal and visual changes may progress even after discontinuation of treatment.

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