唑来膦酸的作用与效果怎么样？

Zoledronic acid can inhibit bone resorption caused by increased osteoclast activity. It is a diphosphate compound that specifically acts on bone. It can inhibit bone resorption, but has no adverse effects on bone formation, bone mineralization and mechanical properties. Today let’s take a closer look at the functions and effects of zoledronic acid?

The functions and effects of zoledronic acid

The main functions of zoledronic acid are to prevent bone destruction, increase bone mass, inhibit bone resorption, treat osteoporosis and assist in the treatment of pain caused by bone destruction. Clinically, it is mainly used for the treatment of osteoporosis and also for the treatment of osteitis deformans. Zoledronic acid increases bone density and enhances bone strength by inhibiting osteoclasts and bone cell resorption.

Zoledronic acid can directly change the morphological structure of osteoclasts and inhibit their "osteoclastic ability." Secondly, it can also affect the self-repair of osteoclasts by affecting the cytokines secreted by osteoblasts, indirectly leading to the apoptosis of osteoclasts, thereby alleviating bone destruction. Zoledronic acid is a third-generation bisphosphonate bone resorption inhibitor and a tumor adjuvant drug, mainly used to relieve pain caused by malignant tumors. Applied once a month, with each infusion lasting no less than 15 minutes, it can effectively treat bone metastases.

When osteoporosis or tumor cells invade bones, the rate of destruction of old cells is accelerated, and the renewal cannot keep up. At this time, the role of zoledronic acid is to inhibit the effect of osteoclasts on bone destruction, repair it, reduce bone damage, and prevent hypercalcemia. General fatigue, chest pain, conjunctivitis, nausea, vomiting, constipation, abdominal pain, hypotension, anemia, etc. are relatively common adverse reactions of zoledronic acid. It is recommended that patients follow the doctor's instructions and receive symptomatic treatment. The above is the content of the functions and effects of zoledronic acid. I hope it can help you!

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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