纳地美定能有效治病吗？

Introduction: Nadimedine is used to treat constipation caused by opioid (narcotic) analgesics and is suitable for adults with chronic (persistent) pain not caused by cancer. Naldemedine belongs to a class of drugs called peripherally acting μ-opioid receptor antagonists, which protect the intestines from the effects of opioid (narcotic) drugs.

Can the generic version of Nadimedine also be effective in treating diseases?

There are currently no generic drugs on the market, and its efficacy cannot be known. The patent rights of Naldemedine are still valid. Therefore, so-called generic versions of Naldemedine do not exist. Any product claiming to be a generic version of Naldemedine may be illegal or unapproved, and its safety and effectiveness cannot be guaranteed.

In order to ensure the safety and effectiveness of treatment, patients are advised to purchase Nadimedine only through legal channels and follow the doctor's instructions during use. If you have any questions or require more information, patients should consult a medical professional or contact a formal pharmaceutical consulting firm for the latest market information.

Efficacy of naldimedine

In a multi-center, double-blind, randomized, placebo-controlled, confirmatory trial, the subjects were cancer patients over 20 years old who had started taking potent opioids regularly for the treatment of cancer pain for the first time. Eligible patients were randomly assigned to the naldimedine group or the placebo group in a 1:1 ratio and received protocol treatment for 14 days. The primary endpoint was the proportion of patients with a bowel function index (BFI) <28.8 on day 14, and secondary endpoints included frequency of spontaneous bowel movements (SBM), quality of life (QOL), and frequency of opioid-induced nausea and vomiting (OINV).

Of 103 eligible patients, 99 received naldimedine (n=49) or placebo (n=50). The incidence of BFI <28.8 on day 14 was significantly higher in the naldemedine group (64.6%) than in the placebo group (17.0%), with an inter-group difference of 47.6%. There were nominally significant differences in SBM frequency, QOL, and OINV severity in the naldimedine group compared with the control group.

The price of Nadimedine

Currently, we know that the price of the Japanese version of Nadimedine 0.2mg*50 tablets per box is about 3800$-4300$, and the price of 0.2mg*14 tablets per box is about 1300$-1900$. The above prices are for reference only and may change due to exchange rate fluctuations, changes in market supply and demand, drug versions, drug specifications and other factors. When actually purchasing, it is recommended to consult the latest price information through formal channels.

Naldemedine prevents constipation and improves constipation-related quality of life and may have preventive effects on OINV in cancer patients starting regular opioid therapy.