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, currently clinically mainly used to treat cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome, and is also suitable for preventing cytomegalovirus infection in high-risk solid organ transplant patients. How to take valganciclovir hydrochloride tablets?

1. Medication management

Oral solution preparation

Wear disposable gloves during reconstitution and when wiping exterior surfaces of bottles/caps and tables after reconstitution

Prior to dispensing, oral solutions must be prepared by a pharmacist as follows

Measure 91mL of pure water in a graduated cylinder

Shake the bottle to loosen the powder; remove the child-resistant bottle cap, add about half the total amount of water, then place the bottle in and shake the closed bottle well for about 1 minute

Add the remaining water and shake the closed bottle well for about 1 minute; the prepared solution contains 50mg/mL

Remove the child-resistant bottle cap and push the bottle adapter into the neck of the bottle

The patient package insert (including dosing instructions for the patient) and 2 oral dispensers should be dispensed to the patient

avoid contact with skin or eyes

If you are exposed to the contents of the oral solution, wash your skin with soap and water or flush your eyes with water.

2. Oral administration

Edible (improves bioavailability)

Handle and dispose of according to the guidelines for antineoplastic agents, as ganciclovir (active metabolite) possesses certain properties of antineoplastic agents (i.e., carcinogenicity and mutagenicity)

3. Storage

Store tablets and undiluted oral solution at 20-25°C (68-77°F); excursions permitted at 15-30°C (59-86°F)

Prepare oral liquid

Store refrigerated at 2-8°C (36-46°F) for no more than 49 days

don't freeze

Write the expiration date of the constituted oral solution on the bottle label

4. Cytomegalovirus retinitis

Indicated for the treatment of CMV retinitis in HIV patients

Induction dose: 900 mg orally every 12 hours for 21 days

Maintenance dose: After induction therapy or in adults without active CMV retinitis, 900 mg PO once daily

5. CMV colitis or esophagitis in HIV-infected patients

Initially treat with ganciclovir 5 mg/kg/dose IV every 12 hours/1 dose; once treatment is tolerated, switch to valganciclovir 900 mg PO once daily for 21-42 days or until signs and symptoms resolve

6. Dosage adjustment

Hepatic Impairment: Safety and effectiveness have not been established

renal insufficiency

CrCl 40-59mL/min: 450mg PO every 12 hours/1 time (induction), then 450mg once daily

CrCl 25-39mL/min: 450mg PO once daily (induction), then 450mg PO once daily

CrCl 10-24mL/min: 450mg PO every 2 days (induction), then 450mg 2x/week

<10 mL/min (during hemodialysis): not recommended

Contraindications: This product should not be used in patients with a known allergic reaction to valganciclovir, ganciclovir or any other component of the drug. Due to the similar chemical structures of valganciclovir hydrochloride tablets to aciclovir and valaciclovir, there may be cross-allergic reactions between these drugs.