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The main ingredient is valganciclovir hydrochloride. Its chemical name is: 1. L-valine, -2[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxy-propyl ester, monohydrochloride. So, what are the indications for Valganciclovir Hydrochloride Tablets?

Valganciclovir hydrochloride tablets are the L-valyl ester (prodrug) of ganciclovir. After oral administration, it is rapidly converted into ganciclovir by esterases in the small intestine and liver. Valganciclovir hydrochloride tablets are a synthetic 2’-deoxyguanylate analogue that inhibits herpes virus replication in vitro and in vivo. Valganciclovir hydrochloride tablets are sensitive to human viruses including human cytomegalovirus (HCMV), and valganciclovir hydrochloride tablets are sensitive to herpes simplex virus-1 and herpes simplex virus-2 (HSV-1, HSV-2), human herpesvirus-6, 7, 8 (HHV-6, 7, 8), Epstein-Barr virus, varicella-zoster virus (VZV) and hepatitis B virus.

Valganciclovir Hydrochloride Tablets In cells infected by cytomegalovirus (CMV), valganciclovir hydrochloride tablets are first phosphorylated by the viral protein kinase UL97 into ganciclovir monophosphate, and then further phosphorylated by intracellular protein kinases into ganciclovir triphosphate, and then slowly metabolized within the cell. After removal of extracellular ganciclovir with Valganciclovir Hydrochloride Tablets, the half-life of ganciclovir in HSV- or HCMV-infected cells was observed to be 18 hours and 6 to 24 hours, respectively. Since the phosphorylation process relies heavily on viral protein kinases, phosphorylation of valganciclovir hydrochloride tablets occurs preferentially in cells infected by the virus.

It is suitable for the treatment of patients with acquired immunodeficiency syndrome (AIDS) combined with cytomegalovirus (CMV) retinitis and the prevention of CMV infection in high-risk solid organ transplant patients.