万赛维适用于治疗什么病症？

(Valcyte) is a pink oval film-coated oral tablet. The main ingredient is valganciclovir hydrochloride. Its chemical name is: 1. L-valine, -2[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxy-propyl ester, monohydrochloride. So what diseases is Vancevi suitable for treating?

Valcyte is mainly used to treat CMV infections such as retinitis, pneumonia, gastroenteritis, liver and central nervous system infections in patients with immunodeficiency. The main feature of ganciclovir is that its efficacy against CMV virus and hepatitis B virus infection is higher than that of currently used general drugs. In vitro experiments have shown that ganciclovir has strong activity against cytomegalovirus, HSV-1, HSV-2, varicella-zoster virus, and Epstein-Barr virus. Its inhibitory activity against cytomegalovirus and Epstein-Barr virus is 50 times stronger than acyclovir and 15 to 19 times stronger than foscarnet. According to Sadeo, ganciclovir can also effectively inhibit human herpes virus 6 (HHV-6) infection during allogeneic hematopoietic stem cell transplantation. It has also been reported that HBV mutant strains with DNA polymerase mutations are resistant to ACV and foscarnet (PFA), but are still sensitive to ganciclovir, indicating that there is another mode of action that is completely different from ACV.

Induction therapy of CMV retinitis: For patients with active CMV retinitis, the recommended dose is 900 mg (two 450 mg tablets) twice daily for 21 days. Prolonged induction therapy may increase the risk of bone marrow toxicity. Maintenance treatment of CMV retinitis: After induction therapy, or in patients with inactive CMV retinitis, the recommended dose is 900 mg (two 450 mg tablets) once daily. Induction therapy may be repeated in patients with worsening retinitis. Prevention of CMV infection in transplant patients: For patients who have received solid organ transplants, the recommended dose is 900 mg (two 450 mg tablets) once daily, starting within 10 days after transplantation and continuing until 100 days after transplantation.