万赛维可以治疗什么病？

The main ingredient is valganciclovir hydrochloride. Its chemical name is: 1. L-valine, -2[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxy-propyl ester, monohydrochloride. What diseases can Vancevi treat?

Vancevi is used to treat patients with acquired immunodeficiency syndrome (AIDS) combined with cytomegalovirus (CMV) retinitis and to prevent CMV infection in high-risk solid organ transplant patients. Vansevir is the L-valyl ester (prodrug) of ganciclovir. Vansevir is rapidly converted into ganciclovir by esterases in the small intestine and liver after oral administration. Vancevir is a synthetic 2’ deoxyguanosine monophosphate analogue that inhibits herpes virus replication in vitro and in vivo.

Human viruses to which Vancevir is sensitive include human cytomegalovirus (HCMV), Vancevir is sensitive to herpes simplex virus-1 and herpes simplex virus-2 (HSV-1, HSV-2), human herpesvirus-6, 7, 8 (HHV-6, 7, 8), Epstein-Barr virus, varicella-zoster virus (VZV) and hepatitis B virus. Valganciclovir Hydrochloride Tablets In cells infected by cytomegalovirus (CMV), valganciclovir hydrochloride tablets are first phosphorylated by the viral protein kinase UL97 into ganciclovir monophosphate, and then further phosphorylated by intracellular protein kinases into ganciclovir triphosphate, and then slowly metabolized within the cell.

After removing extracellular ganciclovir, Vancevir observed that the half-life of ganciclovir in HSV- or HCMV-infected cells was 18 hours and 6 to 24 hours, respectively. Since the phosphorylation process relies heavily on viral protein kinases, phosphorylation of Vancevir occurs preferentially in cells infected by the virus.

Contraindicated in the following patients: Valganciclovir hydrochloride tablets should not be used in patients with a known allergic reaction to valganciclovir, ganciclovir or any other ingredient in the drug. Due to the similar chemical structure of Vancevir to aciclovir and valaciclovir, there may be cross-allergic reactions between these drugs.