盐酸缬更昔洛韦片主治什么？

It is the prodrug of ganciclovir, which is well absorbed from the gastrointestinal tract and rapidly metabolized into ganciclovir in the small intestinal wall and liver. The absolute bioavailability of ganciclovir converted from valganciclovir is approximately 60%. The systemic distribution of valganciclovir is small and transient. The 24-hour area under the curve AUC24 and peak concentration (Cmax) are only 1% and 3% of ganciclovir respectively.

Valganciclovir Hydrochloride Tablets can treat the following symptoms: Prevention of cytomegalovirus (CMV) in high-risk adult kidney, heart, and pancreas transplant patients (donor CMV seropositive/recipient CMV seronegative). Prevention of cytomegalovirus (CMV) in high-risk children with kidney transplantation (4 months to 16 years old) and heart transplantation (1 month to 16 years old). Cytomegalovirus Retinitis, Treatment (AIDS-Related): Treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS).

The antiviral effect of valganciclovir hydrochloride tablets has been clinically confirmed by treating AIDS patients with newly diagnosed retinitis (clinical study WV15376). After 4 weeks of treatment with valganciclovir hydrochloride tablets, the detection rate of CMV virus decreased from 46% (32/69) to 7% (4/55). The U.S. Food and Drug Administration (FDA) approved the increased use of valganciclovir hydrochloride in adult kidney transplant patients at high risk of cytomegalovirus (CMV) disease. The supplemental approval is based on data that longer-term prophylactic treatment with valamciclovir hydrochloride reduced the incidence of CMV disease in high-risk adult kidney transplant patients from 36.8% (for patients treated for 100 days) to 16.8% (for patients treated for 200 days) one year after receiving a kidney transplant) (p <0.0001).1.2 The overall safety profile of valaciclovir hydrochloride does not change when prophylaxis is extended in high-risk renal transplant patients.

Adult patients should use valganciclovir hydrochloride oral solution instead. Oral solutions and tablets should be taken with food. Valaciclovir hydrochloride tablets should not be broken or crushed. Before dispensing the medication to the patient, the pharmacist must prepare an oral solution (50 mg/ml) with valamciclovir hydrochloride.