万赛维主要治疗什么？

It was developed by Roche of Switzerland and launched in China in 2006. It is suitable for the treatment of patients with acquired immunodeficiency syndrome (AIDS) combined with cytomegalovirus (CMV) retinitis and the prevention of CMV infection in high-risk solid organ transplant patients.

  For oral use, the recommended induction dose for the treatment of cytomegalovirus retinitis is 900 mg (two 450 mg tablets) twice daily for 21 days. Maintenance: After induction therapy, or in adult patients with inactive cytomegalovirus retinitis, the recommended dose is 900 mg orally once daily.

Adult patients should use Vancevir tablets rather than Vancevir oral solution. Oral solutions and tablets should be taken with food. Valaciclovir hydrochloride tablets should not be broken or crushed. Before dispensing medication to patients, pharmacists must prepare oral solution (50 mg/ml) with Vancevi.

Vansevir is the L-valyl ester (prodrug) of ganciclovir, which is rapidly converted into ganciclovir by esterases in the small intestine and liver after oral administration. Ganciclovir is a synthetic analog of 2’-deoxyguanosine that inhibits herpes virus replication in vitro and in vivo.

Valcyte is teratogenic. Women should take a pregnancy test before initiating pregnancy and use effective contraception during treatment and within 30 days after treatment; men should use barrier contraception during treatment and within 90 days after treatment. Use with caution in patients with impaired renal function; dose adjustment required. Acute renal failure may occur in elderly patients with or without renal impairment; elderly patients should be used with caution and dosage adjustments based on renal function.

The most common side effects in adults include: diarrhea, low white blood cell, red blood cell and platelet cell counts on blood tests, fever, fatigue, nausea, headache, insomnia, urinary tract infection, shaking movements (tremor), vomiting; side effects with Vancevir are less common and generally mild. If patients experience common side effects while using valganciclovir hydrochloride, they can generally be improved and relieved by suspending the medication.