阿那莫林(Anamorelin)不良反应的处理方法？

The treatment of adverse reactions of Anamorelin needs to be targeted according to the manifestation and severity of the adverse reactions. For example, when hyperglycemia or diabetes worsens, it needs to be treated with oral hypoglycemic drugs, use of insulin, or discontinuation of Anamorelin.

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As an oral mimetic of ghrelin, it improves weight loss, muscle mass, and loss of appetite in patients with cancer cachexia. On January 22, 2021, Anamorelin was approved for production and marketing in Japan for the treatment of cancer cachexia in non-small cell lung cancer, gastric cancer, pancreatic cancer and colorectal cancer.

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1. Blood and lymphatic system diseases: lymphopenia.

2. Eye diseases: eye disorders, eye congestion, foggy vision, and xerophthalmia.

3. Gastrointestinal diseases: nausea, diarrhea, abdominal pain, gastrointestinal bleeding, vomiting, abdominal distension, and esophageal pain.

4. Systemic diseases: fatigue, edema, weakness, chest pain, facial edema, fever, and thirst.

5. Metabolic and malnutrition diseases: impaired glucose tolerance, positive urine glucose, hypertriglyceridemia, hyperglycemia or worsening of diabetes, decreased chloride, increased cholesterol, increased potassium, decreased sodium, and increased triglycerides.

6. Mental and nervous system diseases: headache, dizziness, abnormal taste, peripheral neuropathy, drowsiness, and insomnia.

7. Liver dysfunction: increased AST, increased ALT, increased ALP, increased γ-GTP, and increased bilirubin.

How to deal with adverse reactions of anamorelin

1. Hyperglycemia or worsening of diabetes: When symptoms such as thirst and frequent urination occur, timely hypoglycemic treatment is required. You can take oral hypoglycemic drugs, such as metformin, glibenclamide, rosiglitazone, pioglitazone, etc. You can also use insulin for hypoglycemic treatment. Anamorelin can be stopped if necessary.

2. Eye diseases: Pay attention to resting your eyes during medication, and try to avoid using your eyes for a long time. After using your eyes for a period of time, you can use hot compress, massage and other methods to relieve eye discomfort.

3. Systemic diseases: Avoid fatigue and heavy physical labor during medication, and pay attention to rest. Eat more foods rich in protein, sugar, fat, vitamins, trace minerals and dietary fiber to maintain balanced nutrition. Patients who cannot eat normally can follow the doctor's advice to supplement nutrition through other methods, such as enteral nutrition. Avoid smoking, alcohol, and spicy, greasy, grilled, fried and other irritating foods to avoid irritating the gastrointestinal tract and causing discomfort.

The above measures are for reference only and cannot replace professional medical advice. If you have any discomfort, it is recommended to consult a professional doctor or go directly to the hospital for treatment.

Cachexia is a very typical manifestation of systemic dysfunction, which to a large extent can lead to various complications in patients. Family members are required to pay attention to the patient's physical condition at all times, and to deal with or seek medical treatment in a timely manner once any abnormalities are discovered.

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