替莫唑胺多少钱一盒?在哪里购买?

Temozolomide is a drug used to treat certain types of brain tumors, and its price and availability are critical to patients and their families. This article will explore the price, where to buy, and pharmacokinetic properties of temozolomide in detail, with the goal of providing useful information for patients who need this drug.

How much does a box of temozolomide cost?

The price of the Cipla version in India

The generic version of temozolomide produced by Cipla in India is available in two specifications: the price of 100mg*5 pills is about US$21 per box, while the price of 250mg*5 pills is about US$39 per box. This price setting makes treatment more affordable for more patients.

Cipla’s generic version of temozolomide is not only affordable, but has also passed bioequivalence testing, ensuring similar efficacy to the original drug.

The price of the Indian version of Hydron

The generic version of temozolomide produced by Hydron in India offers three different specifications. Among them, the price of 100mg*5 pills is about US$38 per box, the price of 20mg*5 pills is US$34 per box, and the price of 250mg*5 pills is as high as about US$51 per box.

Although prices vary, these options provide patients with the possibility to choose the treatment that best suits their needs.

Where to buy temozolomide

Regular medical service institutions

Temozolomide has been launched in China and has entered the Chinese medical insurance system, which means that patients can purchase this drug through regular hospitals and medical service institutions. When purchasing, you should carefully check the authenticity of drugs and pay attention to the production date to avoid buying fake or inferior drugs.

Purchasing through legal channels can not only ensure the quality of medicines, but also enjoy the economic benefits brought by medical insurance reimbursement.

Online pharmacies

In addition to traditional medical providers, some reputable online pharmacies may also offer temozolomide. Be especially careful when purchasing online to confirm the legitimacy of the website and the reliability of the source of the drug.

Purchasing from a trusted online platform can provide convenience for patients who find it difficult to visit a hospital or pharmacy in person.

Pharmacokinetics of temozolomide

Absorption and distribution

Adult patients can absorb temozolomide rapidly after oral administration, and the peak plasma concentration can be reached as early as 20 minutes after taking the drug. The average time is 0.5 to 1.5 hours. Taking temozolomide with food will cause a 33% decrease in Cmax and a 9% decrease in the area under the curve (AUC), so it is recommended to take it on an empty stomach.

Temozolomide has an average apparent volume of distribution of 0.4L/kg and a low protein binding rate (10%-20%), which indicates that it is unlikely to interact with other drugs with high protein binding rates.

Metabolism and excretion

Temozolomide is spontaneously hydrolyzed into the active substance MTIC and temozolomide acid metabolites. MTC is further hydrolyzed to 5-amino-imidazole-4amide (AC). Cytochrome P450 plays only a minor role in the metabolism of temozolomide and MTC.

After oral administration of labeled temozolomide, approximately 38% of the total radioactive dose was recovered in excreta within 7 days, most of which was excreted through urine.

Application in special populations

Population pharmacokinetic analysis of temozolomide showed that plasma clearance was not affected by age, renal function or smoking. Plasma pharmacokinetic profiles in patients with mild to moderate hepatic impairment are similar to those in patients with normal hepatic function.

For pediatric patients, although the AUC is higher than that of adults, the maximum tolerated dose per cycle is the same, 1000 mg/m².