首个胆管癌口服药-Incyte公司的培美替尼

On April 17, 2020, the U.S. FDA announced accelerated approval of the FGFR2 inhibitor developed by Incyte to treat adult patients with previously treated advanced cholangiocarcinoma carrying FGFR2 gene fusions or other rearrangements. Pemetinib is the first targeted therapy approved to treat adults with advanced cholangiocarcinoma. Today we will take a closer look at the first oral drug for cholangiocarcinoma - Incyte's pemetinib.

Pemetinib indications: Cholangiocarcinoma that has metastasized (spread to other parts of the body) or is locally advanced and cannot be treated with surgery. Pemetinib is used to treat adults with FGFR2 gene fusions or other changes in the structure of the FGFR2 gene.

The recommended dose of pemetinib is 13.5 mg orally daily for 14 days, followed by 7 days off in a 21-day cycle. Continue treatment until disease progression or unacceptable toxicity. Pemetinib is swallowed whole, with or without food.

American genetic engineering technology company, referred to as Genentech (Incyte), is the oldest biotechnology company in the United States and is currently the second largest biotechnology company in the world after Amgen in terms of scale and strength. In order to achieve the goal of becoming the world's largest oncology pharmaceutical company, Genentech suspended research on the long-acting recombinant human growth hormone Nutroppin Deptot and focused on the research and development of oncology drugs such as Avastin. Genentech is the earliest biotechnology pharmaceutical company established and the first to develop biotechnology drugs.

If the missed dose of pemetinib is less than 4 hours, take the missed dose as soon as possible and then take the next dose at the scheduled time. However, if a dose is missed by 4 hours or more, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed dose.

Use with caution for those with allergies. Many other drugs may also interact with pemetinib, and your doctor should be informed of the drugs you are using, especially St. John's wort. Do not eat large amounts of grapefruit or drink grapefruit juice while taking this medicine.

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Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.